n recent years, the endocannabinoid system has received great interest as a potential therapeutic target in numerous pathological conditions. Cannabinoids have shown an anticancer potential by modulating several pathways involved in cell growth, differentiation, migration, and angiogenesis. However, the therapeutic efficacy of cannabinoids is limited to the treatment of chemotherapy-induced symptoms or cancer pain, but their use as anticancer drugs in chemotherapeutic protocols requires further investigation. In this paper, we reviewed the role of cannabinoids in the modulation of signaling mechanisms implicated in tumor progression.
The endocannabinoid system: A target for cancer treatment / Bifulco, Maurizio; Laezza, Chiara; Pagano, Cristina; Navarra, Giovanna; Pastorino, Olga; Proto Maria Chiara, ; Fiore, Donatella; Piscopo, Chiara; Gazzerro, Patrizia. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 21:3(2020). [10.3390/ijms21030747]
The endocannabinoid system: A target for cancer treatment
Maurizio Bifulco;Laezza Chiara;Pagano Cristina;Navarra Giovanna;Pastorino Olga;Fiore Donatella;Gazzerro Patrizia
2020
Abstract
n recent years, the endocannabinoid system has received great interest as a potential therapeutic target in numerous pathological conditions. Cannabinoids have shown an anticancer potential by modulating several pathways involved in cell growth, differentiation, migration, and angiogenesis. However, the therapeutic efficacy of cannabinoids is limited to the treatment of chemotherapy-induced symptoms or cancer pain, but their use as anticancer drugs in chemotherapeutic protocols requires further investigation. In this paper, we reviewed the role of cannabinoids in the modulation of signaling mechanisms implicated in tumor progression.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
