Purpose of Review: Immune checkpoint inhibitors, such as monoclonal antibodies targeting CTLA-4, PD-1, and PD-L1, have improved the outcome of many malignancies, but serious immune-related cardiovascular adverse events have been observed. Patients’ risk factors for these toxicities are currently being investigated. Recent Findings: Interfering with the CTLA-4 and PD-1 axes can bring to several immune-related adverse events, including cardiotoxic events such as autoimmune myocarditis, pericarditis, and vasculitis, suggesting that these molecules play an important role in preventing autoimmunity. Summary: Risk factors (such as pre-existing cardiovascular conditions, previous and concomitant cardiotoxic treatments, underlying autoimmune diseases, tumor-related factors, simultaneous immune-related toxic effects, and genetic factors) should be always recognized for the correct management of these toxicities.

Cardiovascular Toxicity of Immune Checkpoint Inhibitors: Clinical Risk Factors / Pirozzi, F.; Poto, R.; Aran, L.; Cuomo, A.; Galdiero, M. R.; Spadaro, G.; Abete, P.; Bonaduce, D.; Marone, G.; Tocchetti, C. G.; Varricchi, G.; Mercurio, V.. - In: CURRENT ONCOLOGY REPORTS. - ISSN 1523-3790. - 23:2(2021), p. 13. [10.1007/s11912-020-01002-w]

Cardiovascular Toxicity of Immune Checkpoint Inhibitors: Clinical Risk Factors

Pirozzi F.;Poto R.;Aran L.;Cuomo A.;Galdiero M. R.;Spadaro G.;Abete P.;Bonaduce D.;Marone G.;Tocchetti C. G.
;
Varricchi G.;Mercurio V.
2021

Abstract

Purpose of Review: Immune checkpoint inhibitors, such as monoclonal antibodies targeting CTLA-4, PD-1, and PD-L1, have improved the outcome of many malignancies, but serious immune-related cardiovascular adverse events have been observed. Patients’ risk factors for these toxicities are currently being investigated. Recent Findings: Interfering with the CTLA-4 and PD-1 axes can bring to several immune-related adverse events, including cardiotoxic events such as autoimmune myocarditis, pericarditis, and vasculitis, suggesting that these molecules play an important role in preventing autoimmunity. Summary: Risk factors (such as pre-existing cardiovascular conditions, previous and concomitant cardiotoxic treatments, underlying autoimmune diseases, tumor-related factors, simultaneous immune-related toxic effects, and genetic factors) should be always recognized for the correct management of these toxicities.
2021
Cardiovascular Toxicity of Immune Checkpoint Inhibitors: Clinical Risk Factors / Pirozzi, F.; Poto, R.; Aran, L.; Cuomo, A.; Galdiero, M. R.; Spadaro, G.; Abete, P.; Bonaduce, D.; Marone, G.; Tocchetti, C. G.; Varricchi, G.; Mercurio, V.. - In: CURRENT ONCOLOGY REPORTS. - ISSN 1523-3790. - 23:2(2021), p. 13. [10.1007/s11912-020-01002-w]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/829975
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