Hepatitis-associated aplastic anemia is a well-recognized clinical syndrome in which marrow failure follows the development of hepatitis. Although aplastic anemia is intimately related to paroxysmal nocturnal hemoglobinuria, until now, no cases of PNH-associated hepatitis have been described. We report a case of recurrent acute hepatitis preceding the clinical onset of PNH. Treatment of PNH with the complement inhibitor eculizumab (Soliris®) prevented both recurrences of episodes of intravascular hemolysis and liver enzyme alteration. This is the first known published case of PNH-associated hepatitis.
Bone Marrow of Contention: A Rare Case of Recurrent Acute Hepatitis / Rocco, A.; Compare, D.; Risitano, A. M.; Sgamato, C.; Amato, B.; Nardone, G.. - In: DIGESTIVE DISEASES AND SCIENCES. - ISSN 0163-2116. - 66:(2021), pp. 408-411. [10.1007/s10620-020-06670-z]
Bone Marrow of Contention: A Rare Case of Recurrent Acute Hepatitis
Compare D.;Risitano A. M.;Sgamato C.;Amato B.;Nardone G.
2021
Abstract
Hepatitis-associated aplastic anemia is a well-recognized clinical syndrome in which marrow failure follows the development of hepatitis. Although aplastic anemia is intimately related to paroxysmal nocturnal hemoglobinuria, until now, no cases of PNH-associated hepatitis have been described. We report a case of recurrent acute hepatitis preceding the clinical onset of PNH. Treatment of PNH with the complement inhibitor eculizumab (Soliris®) prevented both recurrences of episodes of intravascular hemolysis and liver enzyme alteration. This is the first known published case of PNH-associated hepatitis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.