Corticotrophin releasing hormone (CRH) is the major regulator of ACTH secretion from the anterior pituitary and acts via CRH-1 receptors (CRH-1R). Corticotropinoma though autonomous still retain their responsiveness to CRH and hence, we hypothesize that in vivo detection of CRH-1 receptors on pituitary adenoma using Gallium-68 ( 68Ga) tagged CRH can indicate the functionality of adenoma and combining it with Positron emission tomography-computed tomography (PET-CT) can provide requisite anatomical information.

Molecular Imaging Targeting Corticotropin Releasing Hormone Receptor for Corticotropinoma: A Changing Paradigm / Walia, Rama; Gupta, Rahul; Bhansali, Anil; Pivonello, Rosario; Kumar, Rajender; Singh, Harmandeep; Ahuja, Chirag; Chhabra, Rajesh; Singh, Apinderpreet; Dhandapani, Sivashanmugam; Sahoo, Sushant; Rana, Nivedita; Vatsa, Rakhee; Dutta, Pinaki; Bhadada, Sanjay Kumar; Sachdeva, Naresh; Mittal, B R; Nahar, Uma; Shukla, Jaya. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. - ISSN 0021-972X. - (2020). [10.1210/clinem/dgaa755]

Molecular Imaging Targeting Corticotropin Releasing Hormone Receptor for Corticotropinoma: A Changing Paradigm

Pivonello, Rosario;
2020

Abstract

Corticotrophin releasing hormone (CRH) is the major regulator of ACTH secretion from the anterior pituitary and acts via CRH-1 receptors (CRH-1R). Corticotropinoma though autonomous still retain their responsiveness to CRH and hence, we hypothesize that in vivo detection of CRH-1 receptors on pituitary adenoma using Gallium-68 ( 68Ga) tagged CRH can indicate the functionality of adenoma and combining it with Positron emission tomography-computed tomography (PET-CT) can provide requisite anatomical information.
2020
Molecular Imaging Targeting Corticotropin Releasing Hormone Receptor for Corticotropinoma: A Changing Paradigm / Walia, Rama; Gupta, Rahul; Bhansali, Anil; Pivonello, Rosario; Kumar, Rajender; Singh, Harmandeep; Ahuja, Chirag; Chhabra, Rajesh; Singh, Apinderpreet; Dhandapani, Sivashanmugam; Sahoo, Sushant; Rana, Nivedita; Vatsa, Rakhee; Dutta, Pinaki; Bhadada, Sanjay Kumar; Sachdeva, Naresh; Mittal, B R; Nahar, Uma; Shukla, Jaya. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. - ISSN 0021-972X. - (2020). [10.1210/clinem/dgaa755]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/823776
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 31
  • ???jsp.display-item.citation.isi??? 20
social impact