Antipsychotic agents modulate key molecules of the postsynaptic density (PSD), including the Homer1a gene, implicated in dendritic spine architecture. How the antipsychotic receptor profile, dose, and duration of administration may influence synaptic plasticity and the Homer1a pattern of expression is yet to be determined.
The Effects of Antipsychotics on the Synaptic Plasticity Gene Homer1a Depend on a Combination of Their Receptor Profile, Dose, Duration of Treatment, and Brain Regions Targeted / Iasevoli, Felice; Buonaguro, Elisabetta Filomena; Avagliano, Camilla; Barone, Annarita; Eramo, Anna; Vellucci, Licia; de Bartolomeis, Andrea. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 21:15(2020). [10.3390/ijms21155555]
The Effects of Antipsychotics on the Synaptic Plasticity Gene Homer1a Depend on a Combination of Their Receptor Profile, Dose, Duration of Treatment, and Brain Regions Targeted
Iasevoli, Felice
;Buonaguro, Elisabetta FilomenaPrimo
Membro del Collaboration Group
;Avagliano, CamillaMembro del Collaboration Group
;Barone, AnnaritaMembro del Collaboration Group
;Vellucci, LiciaMethodology
;de Bartolomeis, AndreaUltimo
Writing – Review & Editing
2020
Abstract
Antipsychotic agents modulate key molecules of the postsynaptic density (PSD), including the Homer1a gene, implicated in dendritic spine architecture. How the antipsychotic receptor profile, dose, and duration of administration may influence synaptic plasticity and the Homer1a pattern of expression is yet to be determined.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
