Vascular function in dilated cardiomyopathy of different etiology has been poorly investigated. Moreover, reference values of flow-mediated dilation (FMD) in chronic heart failure (CHF) need to be updated according to the new standardized protocols. We characterized the vascular impairment in different stages of post-ischemic dilated cardiomyopathy (PI-DC) or idiopathic dilated cardiomyopathy (I-DC). Eighty consecutive outpatients with CHF in different New York Heart Association (NYHA) classes (45 PI-DC, 35 I-DC) and 50 control subjects underwent FMD and brachial distensibility coefficient measurement. Patients with CHF showed a marked impairment in FMD compared with controls that worsened from classes NYHA I-II to III-IV, independently of etiology (P <.05). New York Heart Association I-II PI-DC patients showed a worse FMD compared with NYHA I-II I-DC patients (P <.05). Brachial distensibility coefficient values were significantly lower in patients with CHF compared with controls (P <.001) without differences between PI-DC and I-DC. In conclusion, advanced CHF is characterized by vascular impairment that is independent of etiology. In the early stages of CHF, endothelial dysfunction is more severe in patients with PI-DC compared with I-DC probably due to the high cardiovascular risk profile. In I-DC, vascular function impairment is independent of cardiovascular risk factors and could participate in the pathogenesis of I-DC.

Peripheral Vascular Function in Dilated Cardiomyopathy of Different Etiology / Bosso, Giorgio; Valvano, Antonio; Apuzzi, Valentina; Mercurio, Valentina; Di Simone, Valeria; Cittadini, Antonio; Napoli, Raffaele; Oliviero, Ugo. - In: ANGIOLOGY. - ISSN 0003-3197. - 71:8(2020), pp. 726-733. [10.1177/0003319720932803]

Peripheral Vascular Function in Dilated Cardiomyopathy of Different Etiology

Bosso, Giorgio;Valvano, Antonio;Apuzzi, Valentina;Mercurio, Valentina;Cittadini, Antonio;Napoli, Raffaele;Oliviero, Ugo
2020

Abstract

Vascular function in dilated cardiomyopathy of different etiology has been poorly investigated. Moreover, reference values of flow-mediated dilation (FMD) in chronic heart failure (CHF) need to be updated according to the new standardized protocols. We characterized the vascular impairment in different stages of post-ischemic dilated cardiomyopathy (PI-DC) or idiopathic dilated cardiomyopathy (I-DC). Eighty consecutive outpatients with CHF in different New York Heart Association (NYHA) classes (45 PI-DC, 35 I-DC) and 50 control subjects underwent FMD and brachial distensibility coefficient measurement. Patients with CHF showed a marked impairment in FMD compared with controls that worsened from classes NYHA I-II to III-IV, independently of etiology (P <.05). New York Heart Association I-II PI-DC patients showed a worse FMD compared with NYHA I-II I-DC patients (P <.05). Brachial distensibility coefficient values were significantly lower in patients with CHF compared with controls (P <.001) without differences between PI-DC and I-DC. In conclusion, advanced CHF is characterized by vascular impairment that is independent of etiology. In the early stages of CHF, endothelial dysfunction is more severe in patients with PI-DC compared with I-DC probably due to the high cardiovascular risk profile. In I-DC, vascular function impairment is independent of cardiovascular risk factors and could participate in the pathogenesis of I-DC.
2020
Peripheral Vascular Function in Dilated Cardiomyopathy of Different Etiology / Bosso, Giorgio; Valvano, Antonio; Apuzzi, Valentina; Mercurio, Valentina; Di Simone, Valeria; Cittadini, Antonio; Napoli, Raffaele; Oliviero, Ugo. - In: ANGIOLOGY. - ISSN 0003-3197. - 71:8(2020), pp. 726-733. [10.1177/0003319720932803]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/821089
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