Oral squamous cell carcinoma (OSCC) is the most common secondary solid malignancy after hematopoietic stem‐cell transplantation (HSCT). OSCC following HSCT is frequently preceded by chronic graft‐versus‐host disease (cGVHD). The aim of this study was to describe a cohort of post‐HSCT patients and to evaluate the onset of oral epithelial dysplasia and/or OSCC over time. In this retrospective cohort study, we present a cohort of hematological patients that underwent HSCT. Demographic variables, clinical hematological data, data regarding acute graft‐versus‐host disease (aGVHD) and cGVHD, and oral clinical features were analyzed. We focused on clinicopathological features of a subgroup of 22 patients with oral cGVHD and OSCC after HSCT. Among 80 included patients, 46 patients (57,5%) developed aGVHD and 39 patients (48,7%) developed cGVHD. Oral mucosa was involved in 17 patients with aGVHD (36,9%) and in 22 patients (56,4%) with cGVHD. Out of a total of 22 oral biopsies, roughly 40% revealed mild to moderate dysplasia, and 32 % were OSCC. In the absence of international agreement on the best timing of oral follow‐up after HSCT, it is mandatory to establish a close multidisciplinary evaluation in order to prevent the onset of HSCT-related OSCC and to reduce post‐transplant mortality due to secondary tumors.

Oral dysplastic complications after HSCT: Single case series of multidisciplinary evaluation of 80 patients / Leuci, S.; Coppola, N.; Blasi, A.; Ruoppo, E.; Bizzoca, M. E.; Lo Muzio, L.; Marano, L.; Risitano, A. M.; Mignogna, M. D.. - In: LIFE. - ISSN 2075-1729. - 10:10(2020), pp. 1-11. [10.3390/life10100236]

Oral dysplastic complications after HSCT: Single case series of multidisciplinary evaluation of 80 patients

Leuci S.;Coppola N.
;
Blasi A.;Ruoppo E.;Risitano A. M.;Mignogna M. D.
2020

Abstract

Oral squamous cell carcinoma (OSCC) is the most common secondary solid malignancy after hematopoietic stem‐cell transplantation (HSCT). OSCC following HSCT is frequently preceded by chronic graft‐versus‐host disease (cGVHD). The aim of this study was to describe a cohort of post‐HSCT patients and to evaluate the onset of oral epithelial dysplasia and/or OSCC over time. In this retrospective cohort study, we present a cohort of hematological patients that underwent HSCT. Demographic variables, clinical hematological data, data regarding acute graft‐versus‐host disease (aGVHD) and cGVHD, and oral clinical features were analyzed. We focused on clinicopathological features of a subgroup of 22 patients with oral cGVHD and OSCC after HSCT. Among 80 included patients, 46 patients (57,5%) developed aGVHD and 39 patients (48,7%) developed cGVHD. Oral mucosa was involved in 17 patients with aGVHD (36,9%) and in 22 patients (56,4%) with cGVHD. Out of a total of 22 oral biopsies, roughly 40% revealed mild to moderate dysplasia, and 32 % were OSCC. In the absence of international agreement on the best timing of oral follow‐up after HSCT, it is mandatory to establish a close multidisciplinary evaluation in order to prevent the onset of HSCT-related OSCC and to reduce post‐transplant mortality due to secondary tumors.
2020
Oral dysplastic complications after HSCT: Single case series of multidisciplinary evaluation of 80 patients / Leuci, S.; Coppola, N.; Blasi, A.; Ruoppo, E.; Bizzoca, M. E.; Lo Muzio, L.; Marano, L.; Risitano, A. M.; Mignogna, M. D.. - In: LIFE. - ISSN 2075-1729. - 10:10(2020), pp. 1-11. [10.3390/life10100236]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/819901
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