Large sample sizes are often required to detect statistically significant associations between pharmacogenetic markers and treatment response. Meta-analysis may be performed to synthesize data from several studies, increasing sample size and, consequently, power to detect significant genetic effects. However, performing robust synthesis of data from pharmacogenetic studies is often challenging because of poor reporting of key data in study reports. There is currently no guideline for the reporting of pharmacogenetic studies that has been developed using a widely accepted robust methodology. The objective of this project was to develop the STrengthening the Reporting Of Pharmacogenetic Studies (STROPS) guideline.
STrengthening the Reporting Of Pharmacogenetic Studies: Development of the STROPS guideline / Chaplin, Marty; Kirkham, Jamie J.; Dwan, Kerry; Sloan, Derek J.; Davies, Geraint; Jorgensen, Andrea L.; Aguilar-Delfín, Irma; G Agúndez, José A; M Argon, Sophie; J Arranz, M; A Bennett, Derrick; Böhringer, Stefan; Brody, Lawrence; Cascorbi, Ingolf; Cecchin, Erika; Crommentuijn-van Rhenen, Mandy; K Daly, Ann; Aizati Athirah Daud, Nur; Duconge, Jorge; Fabbri, Chiara; Fitches, Alison; Gaedigk, Andrea; Gemmati, Donato; Maria Dan Hawcutt, Claudia; Huddart, Rachel; Jacqz-Aigrain, Evelyne; M Janković, Slobodan; Katsila, Theodora; Koren, Gideon; S Lipska-Ziętkiewicz, Beata; Liehr, Thomas; H Maitland-van der Zee, A; N Manson, Lisanne E; H Maurer, Martin; Eduardo Megías-Vericat, Juan; Ochi, Taichi; J O'Connor, Daniel; B Ramsey, Laura; Rennert, Gad; Rucci, Francesco; Santulli, Gaetano; Saoulidis, Aris; R Shah, Rashmi; Serretti, Alessandro; Somogyi, Andrew; Sunder-Plassmann, Gere; Boso-Ribelles, Virginia; F Thorn, Caroline; Eirini Tsermpini, Evangelia; Chakradhara Rao Uppugunduri, Satyanarayana; A van Es, Michael; Zarowiecki, Magdalena. - In: PLOS MEDICINE. - ISSN 1549-1676. - 17:9(2020), p. e1003344. [10.1371/journal.pmed.1003344]
STrengthening the Reporting Of Pharmacogenetic Studies: Development of the STROPS guideline
Gaetano SantulliMembro del Collaboration Group
;
2020
Abstract
Large sample sizes are often required to detect statistically significant associations between pharmacogenetic markers and treatment response. Meta-analysis may be performed to synthesize data from several studies, increasing sample size and, consequently, power to detect significant genetic effects. However, performing robust synthesis of data from pharmacogenetic studies is often challenging because of poor reporting of key data in study reports. There is currently no guideline for the reporting of pharmacogenetic studies that has been developed using a widely accepted robust methodology. The objective of this project was to develop the STrengthening the Reporting Of Pharmacogenetic Studies (STROPS) guideline.| File | Dimensione | Formato | |
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