Ochratoxin A (OTA) is a powerful nephrotoxin and the severity of its damage to kidneys depends on both the dose and duration of exposure. According to the scientific data currently available, the mechanism of action still is not completely clarified, but it is supposed that oxidative stress is responsible for OTA-induced nephrotoxicity. Bioactive compound use has emerged as a potential approach to reduce chronic renal failure. Therefore, curcumin (CURC), due to its therapeutic effects, has been chosen for our study to reduce the toxic renal effects induced by OTA. CURC effects are examined in Sprague Dawley rats treated with CURC (100 mg/kg), alone or in combination with OTA (0.5 mg/kg), by gavage daily for 14 days. The end result of the experiment finds rats treated with OTA show alterations in biochemical and oxidative stress parameters in the kidney, related to a decrease in the Glomerular Filtration Rate (GFR). Conversely, the administration of CURC attenuates oxidative stress and ...

Effects of Curcumin on the Renal Toxicity Induced by Ochratoxin A in Rats / Damiano, Sara; Andretta, Emanuela; Longobardi, Consiglia; Prisco, Francesco; Paciello, Orlando; Squillacioti, Caterina; Mirabella, Nicola; Florio, Salvatore; Ciarcia, Roberto. - In: ANTIOXIDANTS. - ISSN 2076-3921. - 9:4(2020), pp. 1-13. [10.3390/antiox9040332]

Effects of Curcumin on the Renal Toxicity Induced by Ochratoxin A in Rats

Sara Damiano;Emanuela Andretta;Francesco Prisco;Orlando Paciello;Caterina Squillacioti;Nicola Mirabella;Salvatore Florio;Roberto Ciarcia
2020

Abstract

Ochratoxin A (OTA) is a powerful nephrotoxin and the severity of its damage to kidneys depends on both the dose and duration of exposure. According to the scientific data currently available, the mechanism of action still is not completely clarified, but it is supposed that oxidative stress is responsible for OTA-induced nephrotoxicity. Bioactive compound use has emerged as a potential approach to reduce chronic renal failure. Therefore, curcumin (CURC), due to its therapeutic effects, has been chosen for our study to reduce the toxic renal effects induced by OTA. CURC effects are examined in Sprague Dawley rats treated with CURC (100 mg/kg), alone or in combination with OTA (0.5 mg/kg), by gavage daily for 14 days. The end result of the experiment finds rats treated with OTA show alterations in biochemical and oxidative stress parameters in the kidney, related to a decrease in the Glomerular Filtration Rate (GFR). Conversely, the administration of CURC attenuates oxidative stress and ...
2020
Effects of Curcumin on the Renal Toxicity Induced by Ochratoxin A in Rats / Damiano, Sara; Andretta, Emanuela; Longobardi, Consiglia; Prisco, Francesco; Paciello, Orlando; Squillacioti, Caterina; Mirabella, Nicola; Florio, Salvatore; Ciarcia, Roberto. - In: ANTIOXIDANTS. - ISSN 2076-3921. - 9:4(2020), pp. 1-13. [10.3390/antiox9040332]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/817048
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