Arginine (L-arginine), is an amino acid involved in a number of biological processes, including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide production. In this systematic review, we focus on the functional role of arginine in the regulation of endothelial function and vascular tone. Both clinical and preclinical studies are examined, analyzing the effects of arginine supplementation in hypertension, ischemic heart disease, aging, peripheral artery disease, and diabetes mellitus.
Arginine and Endothelial Function / Gambardella, Jessica; Khondkar, Wafiq; Morelli, Marco Bruno; Wang, Xujun; Santulli, Gaetano; Trimarco, Valentina. - In: BIOMEDICINES. - ISSN 2227-9059. - 8:8(2020), p. 277. [10.3390/biomedicines8080277]
Arginine and Endothelial Function
Gambardella, JessicaPrimo
Writing – Original Draft Preparation
;Santulli, Gaetano
Supervision
;Trimarco, ValentinaValidation
2020
Abstract
Arginine (L-arginine), is an amino acid involved in a number of biological processes, including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide production. In this systematic review, we focus on the functional role of arginine in the regulation of endothelial function and vascular tone. Both clinical and preclinical studies are examined, analyzing the effects of arginine supplementation in hypertension, ischemic heart disease, aging, peripheral artery disease, and diabetes mellitus.| File | Dimensione | Formato | |
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