Two new sesquiterpenoids belonging to the guaiane, 4α,9α,10α-trihydroxyguaia- 11(13)en-12,6α-olide (1), and germacrane, 9β-hydroxyparthenolide-9-O-β-D-glucopyranoside (2), classes have been isolated fromthe leaves of the Saudi medicinal plant Anvillea garcinii along with seven known compounds (3-9). The structures of the new metabolites were elucidated by spectroscopic analysis, including one-dimensional (1D) and two-dimensional (2D) Nuclear Magnetic Resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESIMS). The antimicrobial properties of 1-9 were screened against seven different pathogenic microbes, and compounds 1-3 showed a potent antifungal activity.
Antibacterial and antifungal sesquiterpenoids from aerial parts of anvillea garcinii / Perveen, S., Alqahtani, J., Orfali, R., Aati, H.Y., Al-Taweel, A.M., Ibrahim, T.A., Khan, A., Yusufoglu, H.S., Abdel-Kader, M.S., Taglialatela-Scafati, O.. - In: MOLECULES. - ISSN 1420-3049. - 25:7(2020), p. 1730. [10.3390/molecules25071730]
Antibacterial and antifungal sesquiterpenoids from aerial parts of anvillea garcinii
Taglialatela-Scafati O.
Ultimo
Conceptualization
2020
Abstract
Two new sesquiterpenoids belonging to the guaiane, 4α,9α,10α-trihydroxyguaia- 11(13)en-12,6α-olide (1), and germacrane, 9β-hydroxyparthenolide-9-O-β-D-glucopyranoside (2), classes have been isolated fromthe leaves of the Saudi medicinal plant Anvillea garcinii along with seven known compounds (3-9). The structures of the new metabolites were elucidated by spectroscopic analysis, including one-dimensional (1D) and two-dimensional (2D) Nuclear Magnetic Resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESIMS). The antimicrobial properties of 1-9 were screened against seven different pathogenic microbes, and compounds 1-3 showed a potent antifungal activity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
