Neutrophils (PMNs) are innate immune cells with primary roles in inflammation and in host defense against infections. Both inflammatory and tumor angiogenesis are modulated by a sequential, coordinated production of angiogenic factors such as vascular endothelial growth factors (VEGFs), angiopoietins, hepatocyte growth factor (HGF), and chemokines. These factors are produced by several immune cells, including PMNs. Activation of cannabinoid receptor type-1 (CB1 ) and -2 (CB2 ) has been suggested as a new strategy to modulate in vitro and in vivo angiogenesis.

LPS-mediated neutrophil VEGF-A release is modulated by cannabinoid receptor activation. GALDIERO IS CO-LAST AUTHOR / Braile, Mariantonia; Cristinziano, Leonardo; Marcella, Simone; Varricchi, Gilda; Marone, Giancarlo; Modestino, Luca; Ferrara, Anne Lise; De Ciuceis, Agnese; Scala, Sara; Galdiero, Maria Rosaria; Loffredo, Stefania. - In: JOURNAL OF LEUKOCYTE BIOLOGY. - ISSN 0741-5400. - 109:3(2021), pp. 621-631. [10.1002/JLB.3A0520-187R]

LPS-mediated neutrophil VEGF-A release is modulated by cannabinoid receptor activation. GALDIERO IS CO-LAST AUTHOR

Braile, Mariantonia;Cristinziano, Leonardo;Marcella, Simone;Varricchi, Gilda;Marone, Giancarlo;Ferrara, Anne Lise;Galdiero, Maria Rosaria
Ultimo
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Loffredo, Stefania
2021

Abstract

Neutrophils (PMNs) are innate immune cells with primary roles in inflammation and in host defense against infections. Both inflammatory and tumor angiogenesis are modulated by a sequential, coordinated production of angiogenic factors such as vascular endothelial growth factors (VEGFs), angiopoietins, hepatocyte growth factor (HGF), and chemokines. These factors are produced by several immune cells, including PMNs. Activation of cannabinoid receptor type-1 (CB1 ) and -2 (CB2 ) has been suggested as a new strategy to modulate in vitro and in vivo angiogenesis.
2021
LPS-mediated neutrophil VEGF-A release is modulated by cannabinoid receptor activation. GALDIERO IS CO-LAST AUTHOR / Braile, Mariantonia; Cristinziano, Leonardo; Marcella, Simone; Varricchi, Gilda; Marone, Giancarlo; Modestino, Luca; Ferrara, Anne Lise; De Ciuceis, Agnese; Scala, Sara; Galdiero, Maria Rosaria; Loffredo, Stefania. - In: JOURNAL OF LEUKOCYTE BIOLOGY. - ISSN 0741-5400. - 109:3(2021), pp. 621-631. [10.1002/JLB.3A0520-187R]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/810450
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