Five-coordinate platinum(II) complexes represent a minority compared to the well-known class of square-planar species. However, since the first appearances in the literature, their general properties have attracted much interest. In particular, their potential to act as anticancer agents has been considered, and several studies have demonstrated their effectiveness as pro-drugs. The review traces the progress of these investigations over time and the subsequent refinements in the structures. It also reports their synthesis, general properties, cytotoxic activity and ability to interact with biological macromolecules.
Five-Coordinate Platinum(II) Compounds as Potential Anticancer Agents / Annunziata, A.; Cucciolito, M. E.; Esposito, R.; Ferraro, G.; Monti, D. M.; Merlino, A.; Ruffo, F.. - In: EUROPEAN JOURNAL OF INORGANIC CHEMISTRY. - ISSN 1434-1948. - 2020:11-12(2020), pp. 918-929. [10.1002/ejic.201900771]
Five-Coordinate Platinum(II) Compounds as Potential Anticancer Agents
Annunziata A.;Cucciolito M. E.;Esposito R.;Ferraro G.;Monti D. M.
;Merlino A.
;Ruffo F.
2020
Abstract
Five-coordinate platinum(II) complexes represent a minority compared to the well-known class of square-planar species. However, since the first appearances in the literature, their general properties have attracted much interest. In particular, their potential to act as anticancer agents has been considered, and several studies have demonstrated their effectiveness as pro-drugs. The review traces the progress of these investigations over time and the subsequent refinements in the structures. It also reports their synthesis, general properties, cytotoxic activity and ability to interact with biological macromolecules.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
