The effects of GRK2 inhibition on myocardial metabolism in heart failure (HF) are unchartered. In this work, we evaluated the impact of pharmacological inhibition of GRK2 by a cyclic peptide, C7, on metabolic, biochemical, and functional phenotypes in experimental HF.
Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart failure / Ciccarelli, M., Sorriento, D., Fiordelisi, A., Gambardella, J., Franco, A., Del Giudice, C., Sala, M., Monti, M.G., Bertamino, A., Campiglia, P., Oliveti, M., Poggio, P., Trinchese, G., Cavaliere, G., Cipolletta, E., Mollica, M.P., Bonaduce, D., Trimarco, B., Iaccarino, G.. - In: ESC HEART FAILURE. - ISSN 2055-5822. - (2020). [10.1002/ehf2.12706]
Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart failure
Sorriento, Daniela;Fiordelisi, Antonella;Gambardella, Jessica;Monti, Maria Gaia;Trinchese, Giovanna;Cavaliere, Gina;Mollica, Maria Pina;Bonaduce, Domenico;Trimarco, Bruno;Iaccarino, Guido
2020
Abstract
The effects of GRK2 inhibition on myocardial metabolism in heart failure (HF) are unchartered. In this work, we evaluated the impact of pharmacological inhibition of GRK2 by a cyclic peptide, C7, on metabolic, biochemical, and functional phenotypes in experimental HF.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
