The effects of GRK2 inhibition on myocardial metabolism in heart failure (HF) are unchartered. In this work, we evaluated the impact of pharmacological inhibition of GRK2 by a cyclic peptide, C7, on metabolic, biochemical, and functional phenotypes in experimental HF.
Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart failure / Ciccarelli, Michele; Sorriento, Daniela; Fiordelisi, Antonella; Gambardella, Jessica; Franco, Antonietta; Del Giudice, Carmine; Sala, Marina; Monti, Maria Gaia; Bertamino, Alessia; Campiglia, Pietro; Oliveti, Marco; Poggio, Paolo; Trinchese, Giovanna; Cavaliere, Gina; Cipolletta, Ersilia; Mollica, Maria Pina; Bonaduce, Domenico; Trimarco, Bruno; Iaccarino, Guido. - In: ESC HEART FAILURE. - ISSN 2055-5822. - (2020). [10.1002/ehf2.12706]
Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart failure
Sorriento, Daniela;Fiordelisi, Antonella;Gambardella, Jessica;Monti, Maria Gaia;Trinchese, Giovanna;Cavaliere, Gina;Mollica, Maria Pina;Bonaduce, Domenico;Trimarco, Bruno;Iaccarino, Guido
2020
Abstract
The effects of GRK2 inhibition on myocardial metabolism in heart failure (HF) are unchartered. In this work, we evaluated the impact of pharmacological inhibition of GRK2 by a cyclic peptide, C7, on metabolic, biochemical, and functional phenotypes in experimental HF.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
