Background: Acute peripheral trauma is a controversial risk factor for idiopathic dystonia. Materials and methods: We retrospectively analyzed data from the Italian Dystonia Registry regarding the occurrence of acute peripheral trauma severe enough to require medical attention in 1382 patients with adult-onset idiopathic dystonia and 200 patients with acquired adult-onset dystonia. Results: Patients with idiopathic and acquired dystonia showed a similar burden of peripheral trauma in terms of the number of patients who experienced trauma (115/1382 vs. 12/200, p = 0.3) and the overall number of injuries (145 for the 1382 idiopathic patients and 14 for the 200 patients with secondary dystonia, p = 0.2). Most traumas occurred before the onset of idiopathic or secondary dystonia but only a minority of such injuries (14 in the idiopathic group, 2 in the acquired group, p = 0.6) affected the same body part as that affected by dystonia. In the idiopathic group, the elapsed time between trauma and dystonia onset was 8.1 ± 9.2 years; only six of the 145 traumas (4.1%) experienced by 5/1382 idiopathic patients (0.36%) occurred one year or less before dystonia onset; in the acquired dystonia group, the two patients experienced prior trauma to the dystonic body part 5 and 6 years before dystonia development. Discussion and conclusion: Our data suggest that the contribution of peripheral acute trauma to idiopathic dystonia is negligible, if anything, and likely involves only a small subset of patients.

Does acute peripheral trauma contribute to idiopathic adult-onset dystonia? / Defazio, G.; Fabbrini, G.; Erro, R.; Albanese, A.; Barone, P.; Zibetti, M.; Esposito, M.; Pellicciari, R.; Avanzino, L.; Bono, F.; Eleopra, R.; Bertolasi, L.; Altavista, M. C.; Cotelli, M. S.; Ceravolo, R.; Scaglione, C.; Bentivoglio, A. R.; Cossu, G.; Coletti Moja, M.; Girlanda, P.; Misceo, S.; Pisani, A.; Mascia, M. M.; Ercoli, T.; Tinazzi, M.; Maderna, L.; Minafra, B.; Magistrelli, L.; Romano, M.; Aguggia, M.; Tambasco, N.; Castagna, A.; Cassano, D.; Berardelli, A.; Ferrazzano, G.; Lalli, S.; Silvestre, F.; Manganelli, F.; Di Biasio, F.; Marchese, R.; Demonte, G.; Santangelo, D.; Devigili, G.; Durastanti, V.; Turla, M.; Mazzucchi, S.; Petracca, M.; Oppo, V.; Barbero, P.; Morgante, F.; Di Lazzaro, G.; Squintani, G.; Modugno, N.. - In: PARKINSONISM & RELATED DISORDERS. - ISSN 1353-8020. - 71:(2020), pp. 40-43. [10.1016/j.parkreldis.2020.01.002]

Does acute peripheral trauma contribute to idiopathic adult-onset dystonia?

Esposito M.;Manganelli F.;
2020

Abstract

Background: Acute peripheral trauma is a controversial risk factor for idiopathic dystonia. Materials and methods: We retrospectively analyzed data from the Italian Dystonia Registry regarding the occurrence of acute peripheral trauma severe enough to require medical attention in 1382 patients with adult-onset idiopathic dystonia and 200 patients with acquired adult-onset dystonia. Results: Patients with idiopathic and acquired dystonia showed a similar burden of peripheral trauma in terms of the number of patients who experienced trauma (115/1382 vs. 12/200, p = 0.3) and the overall number of injuries (145 for the 1382 idiopathic patients and 14 for the 200 patients with secondary dystonia, p = 0.2). Most traumas occurred before the onset of idiopathic or secondary dystonia but only a minority of such injuries (14 in the idiopathic group, 2 in the acquired group, p = 0.6) affected the same body part as that affected by dystonia. In the idiopathic group, the elapsed time between trauma and dystonia onset was 8.1 ± 9.2 years; only six of the 145 traumas (4.1%) experienced by 5/1382 idiopathic patients (0.36%) occurred one year or less before dystonia onset; in the acquired dystonia group, the two patients experienced prior trauma to the dystonic body part 5 and 6 years before dystonia development. Discussion and conclusion: Our data suggest that the contribution of peripheral acute trauma to idiopathic dystonia is negligible, if anything, and likely involves only a small subset of patients.
2020
Does acute peripheral trauma contribute to idiopathic adult-onset dystonia? / Defazio, G.; Fabbrini, G.; Erro, R.; Albanese, A.; Barone, P.; Zibetti, M.; Esposito, M.; Pellicciari, R.; Avanzino, L.; Bono, F.; Eleopra, R.; Bertolasi, L.; Altavista, M. C.; Cotelli, M. S.; Ceravolo, R.; Scaglione, C.; Bentivoglio, A. R.; Cossu, G.; Coletti Moja, M.; Girlanda, P.; Misceo, S.; Pisani, A.; Mascia, M. M.; Ercoli, T.; Tinazzi, M.; Maderna, L.; Minafra, B.; Magistrelli, L.; Romano, M.; Aguggia, M.; Tambasco, N.; Castagna, A.; Cassano, D.; Berardelli, A.; Ferrazzano, G.; Lalli, S.; Silvestre, F.; Manganelli, F.; Di Biasio, F.; Marchese, R.; Demonte, G.; Santangelo, D.; Devigili, G.; Durastanti, V.; Turla, M.; Mazzucchi, S.; Petracca, M.; Oppo, V.; Barbero, P.; Morgante, F.; Di Lazzaro, G.; Squintani, G.; Modugno, N.. - In: PARKINSONISM & RELATED DISORDERS. - ISSN 1353-8020. - 71:(2020), pp. 40-43. [10.1016/j.parkreldis.2020.01.002]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/803122
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