Alcohol abuse is the major cause of experimental and human pancreatitis but the molecular mechanisms remain largely unknown. We investigated the role of transcription factor EB (TFEB), a master regulator of lysosomal biogenesis, in the pathogenesis of alcoholic pancreatitis.
Critical Role of TFEB-Mediated Lysosomal Biogenesis in Alcohol-Induced Pancreatitis in Mice and Humans / Wang, Shaogui; Ni, Hong-Min; Chao, Xiaojuan; Ma, Xiaowen; Kolodecik, Thomas; De Lisle, Robert; Ballabio, Andrea; Pacher, Pal; Ding, Wen-Xing. - In: CMGH. - ISSN 2352-345X. - (2020). [10.1016/j.jcmgh.2020.01.008]
Critical Role of TFEB-Mediated Lysosomal Biogenesis in Alcohol-Induced Pancreatitis in Mice and Humans
Ballabio, Andrea;
2020
Abstract
Alcohol abuse is the major cause of experimental and human pancreatitis but the molecular mechanisms remain largely unknown. We investigated the role of transcription factor EB (TFEB), a master regulator of lysosomal biogenesis, in the pathogenesis of alcoholic pancreatitis.File in questo prodotto:
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