In this paper, we report on the synthesis and spectroscopic characterization of the novel nucleoside 5′-chloro-5′-deoxy-2′,3′-O-isopropylidene-6-fluoro nebularine, obtained as a side product during the second step of the synthesis of 5′-fluoro-5′-deoxy-5-aminoimidazole-4-carboxamide-β-d-riboside (5′-F-AICAR), a non-phosphorylable analogue of 5-aminoimidazole-4-carboxamide-β-d-riboside (AICAR).
5′-chloro-5′-deoxy-2′,3′-o-isopropylidene-6-fluoro nebularine / Falanga, A. P.; Marzano, M.; Terracciano, M.; D'Errico, S.. - In: MOLBANK. - ISSN 1422-8599. - 2019:4(2019), p. M1097. [10.3390/M1097]
5′-chloro-5′-deoxy-2′,3′-o-isopropylidene-6-fluoro nebularine
Falanga A. P.;Marzano M.;Terracciano M.;D'Errico S.
2019
Abstract
In this paper, we report on the synthesis and spectroscopic characterization of the novel nucleoside 5′-chloro-5′-deoxy-2′,3′-O-isopropylidene-6-fluoro nebularine, obtained as a side product during the second step of the synthesis of 5′-fluoro-5′-deoxy-5-aminoimidazole-4-carboxamide-β-d-riboside (5′-F-AICAR), a non-phosphorylable analogue of 5-aminoimidazole-4-carboxamide-β-d-riboside (AICAR).File in questo prodotto:
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