Fatty liver disease is a serious complication of childhood obesity. Calorie-restricted regimen (RCR) is one of the effective therapy for this condition. Aim of the study was to evaluate the effect of lycopene-rich tomato sauce with oregano and basil extracts in obese children with fatty liver on RCR. 61 obese children with fatty liver were enrolled, 52 completed the study. A randomized cross over clinical trial was performed. Participants were assigned to RCR alone or with a supplement of lycopene-rich tomato juice for 60 days; subsequently, the groups were switched to the alternative regimen for the next 60 days. Reduction in BMI, HOMA-IR, cholesterol, triglycerides, liver size, and steatosis was more profound in tomato-supplemented group. Leptin decreased in both groups whereas adiponectin raised only after tomato supplementation. RCR is associated with the impaired engagement of T-cells glycolysis and proliferation, tomato-supplementation resulted in glycolytic metabolic activation of T-cells. Tomato juice ameliorates glucose and lipid metabolism in obese children, improve oxidative and inflammatory state and modulates the mitochondrial metabolism of T-cells contributing to a maintenance of a proper immune surveillance in children, impaired by RCR. The addition of tomato to RCR could be considered a protective and preventive support to obese child.

Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD) / Negri, Rossella; Trinchese, Giovanna; Carbone, Fortunata; Caprio, Maria Grazia; Stanzione, Giovanna; di Scala, Carmen; Micillo, Teresa; Perna, Francesco; Tarotto, Luca; Gelzo, Monica; Cavaliere, Gina; Spagnuolo, Maria Immacolata; Corso, Gaetano; Mattace Raso, Giuseppina; Matarese, Giuseppe; Mollica, Maria Pina; Greco, Luigi; Iorio, Raffaele. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 9:1(2020), pp. E141-E141. [10.3390/jcm9010141]

Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD)

Trinchese, Giovanna
Secondo
;
Carbone, Fortunata;Caprio, Maria Grazia;di Scala, Carmen;Micillo, Teresa;Perna, Francesco;Tarotto, Luca;Gelzo, Monica;Cavaliere, Gina;Spagnuolo, Maria Immacolata;Corso, Gaetano;Mattace Raso, Giuseppina;Matarese, Giuseppe;Mollica, Maria Pina
;
Greco, Luigi;Iorio, Raffaele
2020

Abstract

Fatty liver disease is a serious complication of childhood obesity. Calorie-restricted regimen (RCR) is one of the effective therapy for this condition. Aim of the study was to evaluate the effect of lycopene-rich tomato sauce with oregano and basil extracts in obese children with fatty liver on RCR. 61 obese children with fatty liver were enrolled, 52 completed the study. A randomized cross over clinical trial was performed. Participants were assigned to RCR alone or with a supplement of lycopene-rich tomato juice for 60 days; subsequently, the groups were switched to the alternative regimen for the next 60 days. Reduction in BMI, HOMA-IR, cholesterol, triglycerides, liver size, and steatosis was more profound in tomato-supplemented group. Leptin decreased in both groups whereas adiponectin raised only after tomato supplementation. RCR is associated with the impaired engagement of T-cells glycolysis and proliferation, tomato-supplementation resulted in glycolytic metabolic activation of T-cells. Tomato juice ameliorates glucose and lipid metabolism in obese children, improve oxidative and inflammatory state and modulates the mitochondrial metabolism of T-cells contributing to a maintenance of a proper immune surveillance in children, impaired by RCR. The addition of tomato to RCR could be considered a protective and preventive support to obese child.
2020
Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD) / Negri, Rossella; Trinchese, Giovanna; Carbone, Fortunata; Caprio, Maria Grazia; Stanzione, Giovanna; di Scala, Carmen; Micillo, Teresa; Perna, Francesco; Tarotto, Luca; Gelzo, Monica; Cavaliere, Gina; Spagnuolo, Maria Immacolata; Corso, Gaetano; Mattace Raso, Giuseppina; Matarese, Giuseppe; Mollica, Maria Pina; Greco, Luigi; Iorio, Raffaele. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 9:1(2020), pp. E141-E141. [10.3390/jcm9010141]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/789403
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