Aim: The dramatic emergence of antibiotic resistance has directed the interest of research toward the discovery of novel antimicrobial molecules. In this context, cold-adapted marine bacteria living in polar regions represent an untapped reservoir of biodiversity endowed with an interesting chemical repertoire. The aim of this work was to identify new antimicrobials and/or antibiofilm molecules produced by cold-adapted bacteria. Materials & methods: Organic extracts obtained from polar marine bacteria were tested against Staphylococcus aureus. Most promising samples were subjected to suitable purification strategies. Results: Results obtained led to the identification of a novel lipopeptide able to effectively inhibit the biofilm formation of S. aureus. Conclusion: New lipopeptide may be potentially useful in a wide variety of biotechnological and medical applications.

Cold-adapted bacterial extracts as source of anti-infective and antimicrobial compounds against Staphylococcus aureus / Artini, Marco; Papa, Rosanna; Vrenna, Gianluca; Lauro, Concetta; Ricciardelli, Annarita; Casillo, Angela; Corsaro, Maria M; Tutino, Maria L; Parrilli, Ermenegilda; Selan, Laura. - In: FUTURE MICROBIOLOGY. - ISSN 1746-0913. - 14:16(2019), pp. 1369-1382. [10.2217/fmb-2019-0147]

Cold-adapted bacterial extracts as source of anti-infective and antimicrobial compounds against Staphylococcus aureus

LAURO, CONCETTA;Ricciardelli, Annarita;Casillo, Angela;Corsaro, Maria M;Tutino, Maria L;Parrilli, Ermenegilda;
2019

Abstract

Aim: The dramatic emergence of antibiotic resistance has directed the interest of research toward the discovery of novel antimicrobial molecules. In this context, cold-adapted marine bacteria living in polar regions represent an untapped reservoir of biodiversity endowed with an interesting chemical repertoire. The aim of this work was to identify new antimicrobials and/or antibiofilm molecules produced by cold-adapted bacteria. Materials & methods: Organic extracts obtained from polar marine bacteria were tested against Staphylococcus aureus. Most promising samples were subjected to suitable purification strategies. Results: Results obtained led to the identification of a novel lipopeptide able to effectively inhibit the biofilm formation of S. aureus. Conclusion: New lipopeptide may be potentially useful in a wide variety of biotechnological and medical applications.
2019
Cold-adapted bacterial extracts as source of anti-infective and antimicrobial compounds against Staphylococcus aureus / Artini, Marco; Papa, Rosanna; Vrenna, Gianluca; Lauro, Concetta; Ricciardelli, Annarita; Casillo, Angela; Corsaro, Maria M; Tutino, Maria L; Parrilli, Ermenegilda; Selan, Laura. - In: FUTURE MICROBIOLOGY. - ISSN 1746-0913. - 14:16(2019), pp. 1369-1382. [10.2217/fmb-2019-0147]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/786906
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