In liver cirrhosis, the renin-angiotensin-aldosterone system is involved in the pathogenesis of portal hypertension. Its effector, angiotensin II, is generated by angiotensin-converting enzyme (ACE). Serum ACE levels are affected by I/D polymorphism of its gene, with alleles I and D being associated, respectively, with lesser and greater activity of the enzyme. In cirrhotic patients carrying the ACE I allele, an increased risk for gastro-oesophageal varices was observed.

ACE I allele is associated with more severe portal hypertension in patients with liver cirrhosis: A pilot study / Annicchiarico, B. E.; Santonocito, C.; Siciliano, M.; Scapaticci, M.; Guarino, D.; Di Stasi, C.; Riccioni, M. E.; Di Stasio, E.; Capoluongo, Ettore Domenico; Gasbarrini, A.. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - 51:2(2019), pp. 293-296. [10.1016/j.dld.2018.08.005]

ACE I allele is associated with more severe portal hypertension in patients with liver cirrhosis: A pilot study

Capoluongo;
2019

Abstract

In liver cirrhosis, the renin-angiotensin-aldosterone system is involved in the pathogenesis of portal hypertension. Its effector, angiotensin II, is generated by angiotensin-converting enzyme (ACE). Serum ACE levels are affected by I/D polymorphism of its gene, with alleles I and D being associated, respectively, with lesser and greater activity of the enzyme. In cirrhotic patients carrying the ACE I allele, an increased risk for gastro-oesophageal varices was observed.
2019
ACE I allele is associated with more severe portal hypertension in patients with liver cirrhosis: A pilot study / Annicchiarico, B. E.; Santonocito, C.; Siciliano, M.; Scapaticci, M.; Guarino, D.; Di Stasi, C.; Riccioni, M. E.; Di Stasio, E.; Capoluongo, Ettore Domenico; Gasbarrini, A.. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - 51:2(2019), pp. 293-296. [10.1016/j.dld.2018.08.005]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/779546
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