G protein-coupled receptors (GPCRs) represent the largest family of druggable targets in human genome. Although several GPCRs can cross-talk with the human epidermal growth factor receptors (HERs), the expression and function of most GPCRs remain unknown in HER2+ breast cancer (BC). In this study, we aimed to evaluate gene expression of GPCRs in tumorigenic or anti-HER2 drug-resistant cells and to understand the potential role of candidate GPCRs in HER2+ BC.

GPCRs profiling and identification of GPR110 as a potential new target in HER2+ breast cancer / Bhat, R.R., Yadav, P., Sahay, D., Bhargava, D.K., Creighton, C.J., Yazdanfard, S., Al-rawi, A., Yadav, V., Qin, L., Nanda, S., Sethunath, V., Fu, X., De Angelis, C., Narkar, V.A., Osborne, C.K., Schiff, R., Trivedi, M.V.. - In: BREAST CANCER RESEARCH AND TREATMENT. - ISSN 0167-6806. - 170:2(2018), pp. 279-292. [10.1007/s10549-018-4751-9]

GPCRs profiling and identification of GPR110 as a potential new target in HER2+ breast cancer

De Angelis C.;
2018

Abstract

G protein-coupled receptors (GPCRs) represent the largest family of druggable targets in human genome. Although several GPCRs can cross-talk with the human epidermal growth factor receptors (HERs), the expression and function of most GPCRs remain unknown in HER2+ breast cancer (BC). In this study, we aimed to evaluate gene expression of GPCRs in tumorigenic or anti-HER2 drug-resistant cells and to understand the potential role of candidate GPCRs in HER2+ BC.
2018
GPCRs profiling and identification of GPR110 as a potential new target in HER2+ breast cancer / Bhat, R.R., Yadav, P., Sahay, D., Bhargava, D.K., Creighton, C.J., Yazdanfard, S., Al-rawi, A., Yadav, V., Qin, L., Nanda, S., Sethunath, V., Fu, X., De Angelis, C., Narkar, V.A., Osborne, C.K., Schiff, R., Trivedi, M.V.. - In: BREAST CANCER RESEARCH AND TREATMENT. - ISSN 0167-6806. - 170:2(2018), pp. 279-292. [10.1007/s10549-018-4751-9]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/776667
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 22
  • ???jsp.display-item.citation.isi??? 22
social impact