The incidence of heart failure is ever-growing, and it is urgent to develop improved treatments. An attractive approach is gene therapy; however, the clinical barrier has yet to be broken because of several issues, including the lack of an ideal vector supporting safe and long-term myocardial transgene expression.

Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue / Pleger, S. T.; Most, P.; Boucher, M.; Soltys, S.; Chuprun, J. K.; Pleger, W.; Gao, E.; Dasgupta, A.; Rengo, G.; Remppis, A.; Katus, H. A.; Eckhart, A. D.; Rabinowitz, J. E.; Koch, W. J.. - In: CIRCULATION. - ISSN 0009-7322. - 115:19(2007), pp. 2506-2515. [10.1161/CIRCULATIONAHA.106.671701]

Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue

Rengo G.;
2007

Abstract

The incidence of heart failure is ever-growing, and it is urgent to develop improved treatments. An attractive approach is gene therapy; however, the clinical barrier has yet to be broken because of several issues, including the lack of an ideal vector supporting safe and long-term myocardial transgene expression.
2007
Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue / Pleger, S. T.; Most, P.; Boucher, M.; Soltys, S.; Chuprun, J. K.; Pleger, W.; Gao, E.; Dasgupta, A.; Rengo, G.; Remppis, A.; Katus, H. A.; Eckhart, A. D.; Rabinowitz, J. E.; Koch, W. J.. - In: CIRCULATION. - ISSN 0009-7322. - 115:19(2007), pp. 2506-2515. [10.1161/CIRCULATIONAHA.106.671701]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/774286
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