Editorial in Advances in Molecular Oncology

Introduction to the Special issue “Advances in Molecular Oncology and personalized medicine: individuating molecular targets for intervention and amelioration of patients status”. Editorial. Seminars in Cancer Biology, 2019. Scope of the thematic issue is to provide an update on the effects of modifications (at single nucleotide changes or chromosome translocation), gene silencing by chromatin repression or by mRNA translation block by microRNA activation, and to discuss the possible amplification effects and collaboration between different oncogenic pathways to the development and progression of cancerogenesis process. Driver mutations, epigenetic deregulation, DNA damage, telomere control escape, and changes in RNAs levels affect the cell differentiation state, potentially contributing to the stemness and the proliferation at an embryo-like state, as for cancer stem cells.