Increasing the dose intensity of chemotherapy by more frequent administration or sequential scheduling: a patient-level meta-analysis of 37 298 women with early breast cancer in 26 randomised trials

Gray, R.; Bradley, R.; Braybrooke, J.; Liu, Z.; Peto, R.; Davies, L.; Dodwell, D.; Mcgale, P.; Pan, H.; Taylor, C.; Barlow, W.; Bliss, J.; Bruzzi, P.; Cameron, D.; Fountzilas, G.; Loibl, S.; Mackey, J.; Martin, M.; Del Mastro, L.; Mobus, V.; Nekljudova, V.; De Placido, S.; Swain, S.; Untch, M.; Pritchard, K. I.; Bergh, J.; Norton, L.; Boddington, C.; Burrett, J.; Clarke, M.; Davies, C.; Duane, F.; Evans, V.; Gettins, L.; Godwin, J.; Hills, R.; James, S.; Liu, H.; Mackinnon, E.; Mannu, G.; Mchugh, T.; Morris, P.; Read, S.; Wang, Y.; Wang, Z.; Fasching, P.; Harbeck, N.; Piedbois, P.; Gnant, M.; Steger, G.; Di Leo, A.; Dolci, S.; Francis, P.; Larsimont, D.; Nogaret, J. M.; Philippson, C.; Piccart, M.; Linn, S.; Peer, P.; Tjan-Heijnen, V.; Vliek, S.; Slamon, D.; Bartlett, J.; Bramwell, V. H.; Chen, B.; Chia, S.; Gelmon, K.; Goss, P.; Levine, M.; Parulekar, W.; Pater, J.; Rakovitch, E.; Shepherd, L.; Tu, D.; Whelan, T.; Berry, D.; Broadwater, G.; Cirrincione, C.; Muss, H.; Weiss, R.; Shan, Y.; Shao, Y. F.; Wang, X.; Xu, B.; Zhao, D. -B.; Bartelink, H.; Bijker, N.; Bogaerts, J.; Cardoso, F.; Cufer, T.; Julien, J. -P.; Poortmans, P.; Rutgers, E.; Van De Velde, C.; Carrasco, E.; Segui, M. A.; Blohmer, J. U.; Costa, S.; Gerber, B.; Jackisch, C.; Von Minckwitz, G.; Giuliano, M.; De Laurentiis, M.; Bamia, C.; Koliou, G. -A.; Mavroudis, D.; A'Hern, R.; Ellis, P.; Kilburn, L.; Morden, J.; Yarnold, J.; Sadoon, M.; Tulusan, A. H.; Anderson, S.; Bass, G.; Costantino, J.; Dignam, J.; Fisher, B.; Geyer, C.; Mamounas, E. P.; Paik, S.; Redmond, C.; Wickerham, D. L.; Venturini, M.; Bighin, C.; Pastorino, S.; Pronzato, P.; Sertoli, M. R.; Foukakis, T.; Albain, K.; Arriagada, R.; Bergsten Nordstrom, E.; Boccardo, F.; Brain, E.; Carey, L.; Coates, A.; Coleman, R.; Correa, C.; Cuzick, J.; Davidson, N.; Dowsett, M.; Ewertz, M.; Forbes, J.; Gelber, R.; Goldhirsch, A.; Goodwin, P.; Hayes, D.; Hill, C.; Ingle, J.; Jagsi, R.; Janni, W.; Mukai, H.; Ohashi, Y.; Pierce, L.; Raina, V.; Ravdin, P.; Rea, D.; Regan, M.; Robertson, J.; Sparano, J.; Tutt, A.; Viale, G.; Wilcken, N.; Wolmark, N.; Wood, W.; Zambetti, M.

doi:10.1016/S0140-6736(18)33137-4

Increasing the dose intensity of cytotoxic therapy by shortening the intervals between cycles, or by giving individual drugs sequentially at full dose rather than in lower-dose concurrent treatment schedules, might enhance efficacy.

Increasing the dose intensity of chemotherapy by more frequent administration or sequential scheduling: a patient-level meta-analysis of 37 298 women with early breast cancer in 26 randomised trials / Gray, R., Bradley, R., Braybrooke, J., Liu, Z., Peto, R., Davies, L., Dodwell, D., Mcgale, P., Pan, H., Taylor, C., Barlow, W., Bliss, J., Bruzzi, P., Cameron, D., Fountzilas, G., Loibl, S., Mackey, J., Martin, M., Del Mastro, L., Mobus, V., et al.. - In: THE LANCET. - ISSN 0140-6736. - 393:10179(2019), pp. 1440-1452. [10.1016/S0140-6736(18)33137-4]

Increasing the dose intensity of chemotherapy by more frequent administration or sequential scheduling: a patient-level meta-analysis of 37 298 women with early breast cancer in 26 randomised trials

Gray R.;Bradley R.;Braybrooke J.;Liu Z.;Peto R.;Davies L.;Dodwell D.;McGale P.;Pan H.;Taylor C.;Barlow W.;Bliss J.;Bruzzi P.;Cameron D.;Fountzilas G.;Loibl S.;Mackey J.;Martin M.;Del Mastro L.;Mobus V.;Nekljudova V.;De Placido S.;Swain S.;Untch M.;Pritchard K. I.;Bergh J.;Norton L.;Boddington C.;Burrett J.;Clarke M.;Davies C.;Duane F.;Evans V.;Gettins L.;Godwin J.;Hills R.;James S.;Liu H.;MacKinnon E.;Mannu G.;McHugh T.;Morris P.;Read S.;Wang Y.;Wang Z.;Fasching P.;Harbeck N.;Piedbois P.;Gnant M.;Steger G.;Di Leo A.;Dolci S.;Francis P.;Larsimont D.;Nogaret J. M.;Philippson C.;Piccart M.;Linn S.;Peer P.;Tjan-Heijnen V.;Vliek S.;Slamon D.;Bartlett J.;Bramwell V. H.;Chen B.;Chia S.;Gelmon K.;Goss P.;Levine M.;Parulekar W.;Pater J.;Rakovitch E.;Shepherd L.;Tu D.;Whelan T.;Berry D.;Broadwater G.;Cirrincione C.;Muss H.;Weiss R.;Shan Y.;Shao Y. F.;Wang X.;Xu B.;Zhao D. -B.;Bartelink H.;Bijker N.;Bogaerts J.;Cardoso F.;Cufer T.;Julien J. -P.;Poortmans P.;Rutgers E.;van de Velde C.;Carrasco E.;Segui M. A.;Blohmer J. U.;Costa S.;Gerber B.;Jackisch C.;von Minckwitz G.;Giuliano M.;De Laurentiis M.;Bamia C.;Koliou G. -A.;Mavroudis D.;A'Hern R.;Ellis P.;Kilburn L.;Morden J.;Yarnold J.;Sadoon M.;Tulusan A. H.;Anderson S.;Bass G.;Costantino J.;Dignam J.;Fisher B.;Geyer C.;Mamounas E. P.;Paik S.;Redmond C.;Wickerham D. L.;Venturini M.;Bighin C.;Pastorino S.;Pronzato P.;Sertoli M. R.;Foukakis T.;Albain K.;Arriagada R.;Bergsten Nordstrom E.;Boccardo F.;Brain E.;Carey L.;Coates A.;Coleman R.;Correa C.;Cuzick J.;Davidson N.;Dowsett M.;Ewertz M.;Forbes J.;Gelber R.;Goldhirsch A.;Goodwin P.;Hayes D.;Hill C.;Ingle J.;Jagsi R.;Janni W.;Mukai H.;Ohashi Y.;Pierce L.;Raina V.;Ravdin P.;Rea D.;Regan M.;Robertson J.;Sparano J.;Tutt A.;Viale G.;Wilcken N.;Wolmark N.;Wood W.;Zambetti M.

2019

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				2019
			
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				THE LANCET
			
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				Increasing the dose intensity of chemotherapy by more frequent administration or sequential scheduling: a patient-level meta-analysis of 37 298 women with early breast cancer in 26 randomised trials / Gray, R., Bradley, R., Braybrooke, J., Liu, Z., Peto, R., Davies, L., Dodwell, D., Mcgale, P., Pan, H., Taylor, C., Barlow, W., Bliss, J., Bruzzi, P., Cameron, D., Fountzilas, G., Loibl, S., Mackey, J., Martin, M., Del Mastro, L., Mobus, V., et al.. - In: THE LANCET. - ISSN 0140-6736. - 393:10179(2019), pp. 1440-1452. [10.1016/S0140-6736(18)33137-4]
			
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/771315

Increasing the dose intensity of chemotherapy by more frequent administration or sequential scheduling: a patient-level meta-analysis of 37 298 women with early breast cancer in 26 randomised trials

2019

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Increasing the dose intensity of chemotherapy by more frequent administration or sequential scheduling: a patient-level meta-analysis of 37 298 women with early breast cancer in 26 randomised trials

2019

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