Among the three enzymes involved in the transsulfuration pathway, only cystathionine β-synthase (CBS) converts L-cysteine into L-serine and H2 S. L-serine is also involved in the de novo sphingolipid biosynthesis through a condensation with palmitoyl-CoA by the action of serine palmitoyltransferase (SPT). Here, we have investigated if L-serine contributes to the vasorelaxant effect.

L-cysteine/cystathionine-β-synthase-induced relaxation in mouse aorta involves a L-serine/sphingosine-1-phosphate/NO pathway / Mitidieri, E.; Gurgone, D.; Caiazzo, E.; Tramontano, T.; Cicala, C.; Sorrentino, R.; d'Emmanuele di Villa Bianca, R.. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 0007-1188. - 177:4(2020), pp. 734-744. [10.1111/bph.14654]

L-cysteine/cystathionine-β-synthase-induced relaxation in mouse aorta involves a L-serine/sphingosine-1-phosphate/NO pathway

Mitidieri E.
Primo
;
Gurgone D.;Caiazzo E.;Cicala C.;Sorrentino R.
Penultimo
;
d'Emmanuele di Villa Bianca R.
Ultimo
2020

Abstract

Among the three enzymes involved in the transsulfuration pathway, only cystathionine β-synthase (CBS) converts L-cysteine into L-serine and H2 S. L-serine is also involved in the de novo sphingolipid biosynthesis through a condensation with palmitoyl-CoA by the action of serine palmitoyltransferase (SPT). Here, we have investigated if L-serine contributes to the vasorelaxant effect.
2020
L-cysteine/cystathionine-β-synthase-induced relaxation in mouse aorta involves a L-serine/sphingosine-1-phosphate/NO pathway / Mitidieri, E.; Gurgone, D.; Caiazzo, E.; Tramontano, T.; Cicala, C.; Sorrentino, R.; d'Emmanuele di Villa Bianca, R.. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 0007-1188. - 177:4(2020), pp. 734-744. [10.1111/bph.14654]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/770356
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