BACKGROUND: With the use of non-objective measurement, adherence to growth hormone (GH) therapy has been reported suboptimal in a large proportion of patients, and poor adherence has been shown to affect short-term growth response in patients receiving GH treatment. OBJECTIVE: The Easypod™ electronic device allows objective measurement of adherence. In this study, we report 3-year prospective adherence data of the Italian cohort of naïve GH deficient (GHD) children extrapolated from the Easypod Connect Observational Study (ECOS) database. PATIENTS AND METHODS: Seventy-three GHD children naïve to GH treatment were included in the analysis. 22 Italian centers participated in the study. RESULTS: Mean adherence rate was consistently above 85% across the 3-year observation period. Particularly, mean adherence was 88.5%, 86.6%, and 85.7% after 1, 2 and 3 years, respectively. Mean (± SD) height-SDS increase after the first year was 0.41 (± 0.38). CONCLUSIONS: The majority of naïve GHD children starting GH treatment with Easypod maintained an adherence rate > 85% up to 3 years. Easypod is a useful tool to follow-up patients' adherence allowing timely intervention to improve optimal treatment for these patients.

Adherence to growth hormone (GH) therapy in naïve to treatment GH-deficient children: data of the Italian Cohort from the Easypod Connect Observational Study (ECOS) / Centonze, C.; Guzzetti, C.; Orlando, G.; Loche, S.; Angeletti, C.; Antoniazzi, F.; Bernasconi, S.; Cardinale, G. M.; Caruso-Nicoletti, M.; Cavallo, L.; Cianfarani, S.; Citro, G.; De Luca, F.; Della Casa, S.; Di Pietro, M.; Garofalo, P.; Giordano, C.; Greggio, N. A.; Licenziati, M. R.; Maghnie, M.; Parpagnoli, M.; Persani, L.; Pesce, S.; Sacco, M.; Salerno, M.; Tafi, L.. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 0391-4097. - 42:10(2019), pp. 1241-1244. [10.1007/s40618-019-01046-1]

Adherence to growth hormone (GH) therapy in naïve to treatment GH-deficient children: data of the Italian Cohort from the Easypod Connect Observational Study (ECOS)

Salerno M.;
2019

Abstract

BACKGROUND: With the use of non-objective measurement, adherence to growth hormone (GH) therapy has been reported suboptimal in a large proportion of patients, and poor adherence has been shown to affect short-term growth response in patients receiving GH treatment. OBJECTIVE: The Easypod™ electronic device allows objective measurement of adherence. In this study, we report 3-year prospective adherence data of the Italian cohort of naïve GH deficient (GHD) children extrapolated from the Easypod Connect Observational Study (ECOS) database. PATIENTS AND METHODS: Seventy-three GHD children naïve to GH treatment were included in the analysis. 22 Italian centers participated in the study. RESULTS: Mean adherence rate was consistently above 85% across the 3-year observation period. Particularly, mean adherence was 88.5%, 86.6%, and 85.7% after 1, 2 and 3 years, respectively. Mean (± SD) height-SDS increase after the first year was 0.41 (± 0.38). CONCLUSIONS: The majority of naïve GHD children starting GH treatment with Easypod maintained an adherence rate > 85% up to 3 years. Easypod is a useful tool to follow-up patients' adherence allowing timely intervention to improve optimal treatment for these patients.
2019
Adherence to growth hormone (GH) therapy in naïve to treatment GH-deficient children: data of the Italian Cohort from the Easypod Connect Observational Study (ECOS) / Centonze, C.; Guzzetti, C.; Orlando, G.; Loche, S.; Angeletti, C.; Antoniazzi, F.; Bernasconi, S.; Cardinale, G. M.; Caruso-Nicoletti, M.; Cavallo, L.; Cianfarani, S.; Citro, G.; De Luca, F.; Della Casa, S.; Di Pietro, M.; Garofalo, P.; Giordano, C.; Greggio, N. A.; Licenziati, M. R.; Maghnie, M.; Parpagnoli, M.; Persani, L.; Pesce, S.; Sacco, M.; Salerno, M.; Tafi, L.. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 0391-4097. - 42:10(2019), pp. 1241-1244. [10.1007/s40618-019-01046-1]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/767604
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