The IGF and mTOR-pathways are considered as potential targets for therapy in patients with adrenocortical carcinoma (ACC). This study aims to describe the IGF pathway in ACC and to explore the response to the combined treatment with the IGF1R/IR inhibitor linsitinib, and mTOR inhibitors (sirolimus and everolimus) in in vitro models of ACC.

IGF and mTOR pathway expression and in vitro effects of linsitinib and mTOR inhibitors in adrenocortical cancer / De Martino, M. C.; van Koetsveld, P. M.; Feelders, R. A.; de Herder, W. W.; Dogan, F.; Janssen, J. A. M. J. L.; Hofste op Bruinink, D.; Pivonello, C.; Waaijers, A. M.; Colao, A.; de Krijger, R. R.; Pivonello, R.; Hofland, L. J.. - In: ENDOCRINE. - ISSN 1355-008X. - 64:3(2019), pp. 673-684. [10.1007/s12020-019-01869-1]

IGF and mTOR pathway expression and in vitro effects of linsitinib and mTOR inhibitors in adrenocortical cancer

De Martino M. C.;Pivonello C.;Colao A.;Pivonello R.;
2019

Abstract

The IGF and mTOR-pathways are considered as potential targets for therapy in patients with adrenocortical carcinoma (ACC). This study aims to describe the IGF pathway in ACC and to explore the response to the combined treatment with the IGF1R/IR inhibitor linsitinib, and mTOR inhibitors (sirolimus and everolimus) in in vitro models of ACC.
2019
IGF and mTOR pathway expression and in vitro effects of linsitinib and mTOR inhibitors in adrenocortical cancer / De Martino, M. C.; van Koetsveld, P. M.; Feelders, R. A.; de Herder, W. W.; Dogan, F.; Janssen, J. A. M. J. L.; Hofste op Bruinink, D.; Pivonello, C.; Waaijers, A. M.; Colao, A.; de Krijger, R. R.; Pivonello, R.; Hofland, L. J.. - In: ENDOCRINE. - ISSN 1355-008X. - 64:3(2019), pp. 673-684. [10.1007/s12020-019-01869-1]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/766324
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