Abstract Melanoma delivers immune suppressive stimuli through PDL-1. FK506 binding protein 51 (FKBP51) is an immunophilin capable of immune suppression. We, previously, demonstrated a relevant role for this protein in melanoma biology and progression. Melanoma also expresses a splicing variant of FKBP51 (isoform 2 or ISO2), whose function is unknown. Aim of this study was to generate knowledge on the mechanism regulating PDL- 1 expression in melanoma, and find biomarkers predictive of response to immunotherapy.
The isoform 2 of FKBP51 is induced by PDL-1/PD1 interaction and marks peripheral blood mononuclear cells of melanoma patients / Romano, MARIA FIAMMETTA; D'Angelillo, Anna; Romano, Simona; Simeone, Ester; Ascierto, Paolo; Staibano, Stefania; D'Arrigo, Paolo; Scalvenzi, Massimiliano; Ilardi, Gennaro; Bisogni, Rita. - In: CANCER RESEARCH. - ISSN 0008-5472. - 74:19(2014), pp. 2912-2912. [10.1158/1538-7445.AM2014-2912]
The isoform 2 of FKBP51 is induced by PDL-1/PD1 interaction and marks peripheral blood mononuclear cells of melanoma patients
ROMANO, MARIA FIAMMETTA;D'ANGELILLO, ANNA;ROMANO, SIMONA;STAIBANO, STEFANIA;SCALVENZI, MASSIMILIANO;ILARDI, GENNARO;BISOGNI, RITA
2014
Abstract
Abstract Melanoma delivers immune suppressive stimuli through PDL-1. FK506 binding protein 51 (FKBP51) is an immunophilin capable of immune suppression. We, previously, demonstrated a relevant role for this protein in melanoma biology and progression. Melanoma also expresses a splicing variant of FKBP51 (isoform 2 or ISO2), whose function is unknown. Aim of this study was to generate knowledge on the mechanism regulating PDL- 1 expression in melanoma, and find biomarkers predictive of response to immunotherapy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
