Metabolic alterations leading to overactivation of nutrient-energy-sensing pathways have been linked to altered immunological self-tolerance. Now, Zhang and colleagues (Immunity, 2019) have identified a key role for high glucose consumption in exacerbating autoimmunity in mice via induction of T helper (Th)17 cells. This reveals a novel mechanism underlying effects of diet during autoimmunity development with major translational implications.
The Sweet Kiss Breaching Immunological Self-Tolerance / Galgani, M.; Matarese, G.. - In: TRENDS IN MOLECULAR MEDICINE. - ISSN 1471-4914. - 25:10(2019), pp. 819-820. [10.1016/j.molmed.2019.08.003]
The Sweet Kiss Breaching Immunological Self-Tolerance
Galgani M.;Matarese G.
2019
Abstract
Metabolic alterations leading to overactivation of nutrient-energy-sensing pathways have been linked to altered immunological self-tolerance. Now, Zhang and colleagues (Immunity, 2019) have identified a key role for high glucose consumption in exacerbating autoimmunity in mice via induction of T helper (Th)17 cells. This reveals a novel mechanism underlying effects of diet during autoimmunity development with major translational implications.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
