Increasing pancreatic β-cell proliferation in autoimmune type 1 diabetes (T1D) might restore β-cell mass but would be predicted to exacerbate islet inflammation. A study in Nature Metabolism, however, reports that boosting β-cell proliferation in mouse models of T1D is beneficial, preserving the immunological self-tolerance of islets through the induction of regulatory T cells.
Divide and hide: proliferating β-cells control immune tolerance in autoimmune diabetes / Galgani, M.; Matarese, G.. - In: NATURE METABOLISM. - ISSN 2522-5812. - 1:5(2019), pp. 499-500. [10.1038/s42255-019-0068-1]
Divide and hide: proliferating β-cells control immune tolerance in autoimmune diabetes
Galgani M.;Matarese G.
2019
Abstract
Increasing pancreatic β-cell proliferation in autoimmune type 1 diabetes (T1D) might restore β-cell mass but would be predicted to exacerbate islet inflammation. A study in Nature Metabolism, however, reports that boosting β-cell proliferation in mouse models of T1D is beneficial, preserving the immunological self-tolerance of islets through the induction of regulatory T cells.File in questo prodotto:
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