In insects, rapidly evolving primary sex-determining signals are transduced by a conserved regulatory module controlling sexual differentiation. In the agricultural pest, Ceratitis capitata, we identified a Y-linked gene, Maleness-on the-Y (MoY), encoding a small protein that is necessary and sufficient for male development. Silencing or disruption of MoY in XY embryos causes feminization, while overexpression of MoY in XX embryos induces masculinization. Notably, crosses between transformed XY females and XX males give rise to males and females, indicating that a Y chromosome can be transmitted by XY females. Interestingly, MoY is Y-linked and functionally conserved in other species of the Tephritidae family, highlighting its potential to serve as a tool for developing more effective control strategies against these major agricultural insect pests.
Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests
Meccariello A.Primo
Investigation
;Salvemini M.Secondo
Methodology
;Primo P.Investigation
;Ippolito D.Investigation
;Monti S. M.Investigation
;Petrella V.Investigation
;Ruggiero A.Investigation
;Giordano E.Investigation
;Saccone G.
Ultimo
Writing – Original Draft Preparation
2019
Abstract
In insects, rapidly evolving primary sex-determining signals are transduced by a conserved regulatory module controlling sexual differentiation. In the agricultural pest, Ceratitis capitata, we identified a Y-linked gene, Maleness-on the-Y (MoY), encoding a small protein that is necessary and sufficient for male development. Silencing or disruption of MoY in XY embryos causes feminization, while overexpression of MoY in XX embryos induces masculinization. Notably, crosses between transformed XY females and XX males give rise to males and females, indicating that a Y chromosome can be transmitted by XY females. Interestingly, MoY is Y-linked and functionally conserved in other species of the Tephritidae family, highlighting its potential to serve as a tool for developing more effective control strategies against these major agricultural insect pests.File | Dimensione | Formato | |
---|---|---|---|
aax1318 printed MoY paper Science Meccariello .pdf
accesso aperto
Descrizione: articolo principale
Tipologia:
Versione Editoriale (PDF)
Licenza:
Accesso privato/ristretto
Dimensione
977.63 kB
Formato
Adobe PDF
|
977.63 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.