T-cell development in the thymus is a complex and highly regulated process, involving a wide variety of cells and molecules which orchestrate thymocyte maturation into either CD4+ or CD8+ single-positive (SP) T cells. Here, we briefly review the process regulating T-cell differentiation, which includes the latest advances in this field. In particular, we highlight how, starting from a pool of hematopoietic stem cells in the bone marrow, the sequential action of transcriptional factors and cytokines dictates the proliferation, restriction of lineage potential, T-cell antigen receptors (TCR) gene rearrangements, and selection events on the T-cell progenitors, ultimately leading to the generation of mature T cells. Moreover, this review discusses paradigmatic examples of viral infections affecting the thymus that, by inducing functional changes within this lymphoid gland, consequently influence the behavior of peripheral mature T-lymphocytes.

Insights into Thymus Development and Viral Thymic Infections / Albano, F.; Vecchio, E.; Renna, M.; Iaccino, E.; Mimmi, S.; Caiazza, C.; Arcucci, A.; Avagliano, A.; Pagliara, V.; Donato, G.; Palmieri, C.; Mallardo, M.; Quinto, I.; Fiume, G.. - In: VIRUSES. - ISSN 1999-4915. - 11:9(2019), pp. 1-19. [10.3390/v11090836]

Insights into Thymus Development and Viral Thymic Infections

Albano F.
Membro del Collaboration Group
;
Renna M.
Membro del Collaboration Group
;
Caiazza C.
Membro del Collaboration Group
;
Arcucci A.
Membro del Collaboration Group
;
Mallardo M.
Membro del Collaboration Group
;
2019

Abstract

T-cell development in the thymus is a complex and highly regulated process, involving a wide variety of cells and molecules which orchestrate thymocyte maturation into either CD4+ or CD8+ single-positive (SP) T cells. Here, we briefly review the process regulating T-cell differentiation, which includes the latest advances in this field. In particular, we highlight how, starting from a pool of hematopoietic stem cells in the bone marrow, the sequential action of transcriptional factors and cytokines dictates the proliferation, restriction of lineage potential, T-cell antigen receptors (TCR) gene rearrangements, and selection events on the T-cell progenitors, ultimately leading to the generation of mature T cells. Moreover, this review discusses paradigmatic examples of viral infections affecting the thymus that, by inducing functional changes within this lymphoid gland, consequently influence the behavior of peripheral mature T-lymphocytes.
2019
Insights into Thymus Development and Viral Thymic Infections / Albano, F.; Vecchio, E.; Renna, M.; Iaccino, E.; Mimmi, S.; Caiazza, C.; Arcucci, A.; Avagliano, A.; Pagliara, V.; Donato, G.; Palmieri, C.; Mallardo, M.; Quinto, I.; Fiume, G.. - In: VIRUSES. - ISSN 1999-4915. - 11:9(2019), pp. 1-19. [10.3390/v11090836]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/761689
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