The encapsulation of anticancer metal-based drugs within a protein nanocage represents a valuable strategy to improve the efficacy and selectivity of these compounds towards cancer cells. The preparation, characterization of the in vitro cytotoxicity and X-ray structures of several ferritin-metallodrug nanocomposites (mainly containing platinum-, ruthenium- and gold-based anticancer agents) are here reviewed. The molecular mechanisms of action of these Ft-metallodrug adducts are discussed and future directions in the field are outlined
Ferritin-based anticancer metallodrug delivery: Crystallographic, analytical and cytotoxicity studies / Monti, D. M.; Ferraro, G.; Merlino, A.. - In: NANOMEDICINE. - ISSN 1549-9634. - 20:(2019), p. 101997. [10.1016/j.nano.2019.04.001]
Ferritin-based anticancer metallodrug delivery: Crystallographic, analytical and cytotoxicity studies
Monti D. M.;Ferraro G.;Merlino A.
2019
Abstract
The encapsulation of anticancer metal-based drugs within a protein nanocage represents a valuable strategy to improve the efficacy and selectivity of these compounds towards cancer cells. The preparation, characterization of the in vitro cytotoxicity and X-ray structures of several ferritin-metallodrug nanocomposites (mainly containing platinum-, ruthenium- and gold-based anticancer agents) are here reviewed. The molecular mechanisms of action of these Ft-metallodrug adducts are discussed and future directions in the field are outlinedI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
