Most essential physiological functions in mammals show a 24-h rhythmic pattern, which includes sleep-wake, feeding-non-feeding cycles and energy metabolism. Recent studies indicate that macroautophagy/autophagy also displays a robust circadian rhythmicity following the daily feeding pattern in adult mammals. We discovered that MiT-TFE transcription factors TFEB and TFE3, master regulators of autophagy and lysosomal biogenesis, are activated in a circadian manner and drive the expression of NR1D1/REV-ERBα, a key component of the core clockwork, thus revealing a molecular link between the nutrient-driven circadian cycle and the light-induced molecular clock. The dynamic balance between TFEB and TFE3 activation and NR1D1 expression is responsible for the modulation and oscillation of autophagy and metabolism genes.

Keeping the autophagy tempo / Pastore, Nunzia; Ballabio, Andrea. - In: AUTOPHAGY. - ISSN 1554-8627. - (2019), pp. 1-3-3. [10.1080/15548627.2019.1645545]

Keeping the autophagy tempo

Pastore, Nunzia;Ballabio, Andrea
2019

Abstract

Most essential physiological functions in mammals show a 24-h rhythmic pattern, which includes sleep-wake, feeding-non-feeding cycles and energy metabolism. Recent studies indicate that macroautophagy/autophagy also displays a robust circadian rhythmicity following the daily feeding pattern in adult mammals. We discovered that MiT-TFE transcription factors TFEB and TFE3, master regulators of autophagy and lysosomal biogenesis, are activated in a circadian manner and drive the expression of NR1D1/REV-ERBα, a key component of the core clockwork, thus revealing a molecular link between the nutrient-driven circadian cycle and the light-induced molecular clock. The dynamic balance between TFEB and TFE3 activation and NR1D1 expression is responsible for the modulation and oscillation of autophagy and metabolism genes.
2019
Keeping the autophagy tempo / Pastore, Nunzia; Ballabio, Andrea. - In: AUTOPHAGY. - ISSN 1554-8627. - (2019), pp. 1-3-3. [10.1080/15548627.2019.1645545]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/757510
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