Vitamin D and calcium are considered crucial for the treatment of bone diseases. Both vitamin D and calcium contribute to bone homeostasis but also preserve muscle health by reducing the risk of falls and fractures. Low vitamin D concentrations result in secondary hyperparathyroidism and contribute to bone loss, although the development of secondary hyperparathyroidism varies, even in patients with severe vitamin D deficiency. Findings from observational studies have shown controversial results regarding to the association between bone mineral density and vitamin D/calcium status, thus sparking a debate regarding optimum concentrations of 25-hydroxyvitamin D and calcium for the best possible skeletal health. Although most of intervention studies reported a positive effect of supplementation with calcium and vitamin D on bone in patients with osteoporosis, this therapeutic approach has been a matter of debate regarding potential side effects on the cardiovascular (CV) system. Thus, the aim of this review is to consider the current evidence on the physiological role of vitamin D and calcium on bone and muscle health. Moreover, we provide an overview on observational and interventional studies that investigate the effect of vitamin D and calcium supplementation on bone health, also taking into account the possible CV side-effects. We also provide molecular insights on the effect of calcium plus vitamin D on the CV system.

Calcium and vitamin D supplementation. Myths and realities with regard to cardiovascular risk / Muscogiuri, Giovanna; Barrea, Luigi; Altieri, Barbara; Di Somma, Carolina; Bhattoa, Harjitpal; Laudisio, Daniela; Duval, Guillaume T; Pugliese, Gabriella; Annweiler, Cédric; Orio, Francesco; Fakhouri, Hana; Savastano, Silvia; Colao, Annamaria. - In: CURRENT VASCULAR PHARMACOLOGY. - ISSN 1570-1611. - 17:(2019). [10.2174/1570161117666190408165805]

Calcium and vitamin D supplementation. Myths and realities with regard to cardiovascular risk

Muscogiuri, Giovanna
;
Barrea, Luigi;Di Somma, Carolina;PUGLIESE, GABRIELLA;Orio, Francesco;Savastano, Silvia;Colao, Annamaria
2019

Abstract

Vitamin D and calcium are considered crucial for the treatment of bone diseases. Both vitamin D and calcium contribute to bone homeostasis but also preserve muscle health by reducing the risk of falls and fractures. Low vitamin D concentrations result in secondary hyperparathyroidism and contribute to bone loss, although the development of secondary hyperparathyroidism varies, even in patients with severe vitamin D deficiency. Findings from observational studies have shown controversial results regarding to the association between bone mineral density and vitamin D/calcium status, thus sparking a debate regarding optimum concentrations of 25-hydroxyvitamin D and calcium for the best possible skeletal health. Although most of intervention studies reported a positive effect of supplementation with calcium and vitamin D on bone in patients with osteoporosis, this therapeutic approach has been a matter of debate regarding potential side effects on the cardiovascular (CV) system. Thus, the aim of this review is to consider the current evidence on the physiological role of vitamin D and calcium on bone and muscle health. Moreover, we provide an overview on observational and interventional studies that investigate the effect of vitamin D and calcium supplementation on bone health, also taking into account the possible CV side-effects. We also provide molecular insights on the effect of calcium plus vitamin D on the CV system.
2019
Calcium and vitamin D supplementation. Myths and realities with regard to cardiovascular risk / Muscogiuri, Giovanna; Barrea, Luigi; Altieri, Barbara; Di Somma, Carolina; Bhattoa, Harjitpal; Laudisio, Daniela; Duval, Guillaume T; Pugliese, Gabriella; Annweiler, Cédric; Orio, Francesco; Fakhouri, Hana; Savastano, Silvia; Colao, Annamaria. - In: CURRENT VASCULAR PHARMACOLOGY. - ISSN 1570-1611. - 17:(2019). [10.2174/1570161117666190408165805]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/756892
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