Changes in densities and in the morphology of dendritic spines in the hippocampus are linked to hippocampal long-term potentiation (LTP), spatial learning, and depression. Decreased brain-derived neurotrophic factor (BDNF) levels seem to contribute to depression. Through its receptor trkB, BDNF is also involved in hippocampal LTP and hippocampus-dependent learning. Conditionally gene-targeted mice in which the ablation of trkB is restricted to the forebrain and occurs only during postnatal development display impaired learning and LTP.
Regional- and age-dependent reduction in trkB receptor expression in the hippocampus is associated with altered spine morphologies / von Bohlen und Halbach, Oliver; Krause, Sonja; Medina, Diego; Sciarretta, Carla; Minichiello, Liliana; Unsicker, Klaus. - In: BIOLOGICAL PSYCHIATRY. - ISSN 0006-3223. - 59:9(2006), pp. 793-800-800. [10.1016/j.biopsych.2005.08.025]
Regional- and age-dependent reduction in trkB receptor expression in the hippocampus is associated with altered spine morphologies
Medina, Diego;
2006
Abstract
Changes in densities and in the morphology of dendritic spines in the hippocampus are linked to hippocampal long-term potentiation (LTP), spatial learning, and depression. Decreased brain-derived neurotrophic factor (BDNF) levels seem to contribute to depression. Through its receptor trkB, BDNF is also involved in hippocampal LTP and hippocampus-dependent learning. Conditionally gene-targeted mice in which the ablation of trkB is restricted to the forebrain and occurs only during postnatal development display impaired learning and LTP.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
