New five-coordinate Pt(II) complexes containing a glycosylated carbene fragment were synthesized. A member of this class shows very high in vitro cytotoxicity and an exceptional selectivity toward malignant cells. The complex lacking the sugary portion fails in the recognition of cancer cells. The results support the use of glycosylation in the design of carbene Pt-based anticancer agents.
A highly efficient and selective antitumor agent based on a glucoconjugated carbene platinum(ii) complex / Annunziata, Alfonso; Cucciolito, Maria Elena; Esposito, Roberto; Imbimbo, Paola; Petruk, Ganna; Ferraro, Giarita; Pinto, Valerio; Tuzi, Angela; Monti, Daria Maria; Merlino, Antonello; Ruffo, Francesco. - In: DALTON TRANSACTIONS. - ISSN 1477-9226. - 48:22(2019), pp. 7794-7800. [10.1039/C9DT01614G]
A highly efficient and selective antitumor agent based on a glucoconjugated carbene platinum(ii) complex
ANNUNZIATA, ALFONSO;Cucciolito, Maria Elena;Esposito, Roberto;Imbimbo, Paola;Petruk, Ganna;Ferraro, Giarita;Pinto, Valerio;Tuzi, Angela;Monti, Daria Maria
;Merlino, Antonello
;Ruffo, Francesco
2019
Abstract
New five-coordinate Pt(II) complexes containing a glycosylated carbene fragment were synthesized. A member of this class shows very high in vitro cytotoxicity and an exceptional selectivity toward malignant cells. The complex lacking the sugary portion fails in the recognition of cancer cells. The results support the use of glycosylation in the design of carbene Pt-based anticancer agents.| File | Dimensione | Formato | |
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