It is increasingly evident that an understanding of both the functional repertoire and the behavioral plasticity of neural circuits - here referred to as the circuit's performative capacity - cannot be solely based on the knowledge of neural connectivity diagrams and their variations. The performative capacity of a neural circuit is indeed qualitatively altered in a rapid and reversible way by various substances, called neuromodulators, in the extracellular fluid. This paper focuses on two properties of neuromodulatory action that are relatively neglected in current computational models of neuromodulation: the functional soundness of neuromodulated circuits and the robustness of neuromodulatory action. Both properties are examined here as sources of functional specifications for computational models of neuromodulatory action. In particular, it is pointed out that in a computational model based on CTRNNs (Continuous Time Recurrent Neural Networks) robustness can be modeled through a hysteresis process and functional soundness through a multiplicity of stable fixed points of the dynamic system.

Neuromodulazione e capacità performative dei circuiti neurali. verso una modellistica computazionale

R. Prevete;G. Tamburrini
2018

Abstract

It is increasingly evident that an understanding of both the functional repertoire and the behavioral plasticity of neural circuits - here referred to as the circuit's performative capacity - cannot be solely based on the knowledge of neural connectivity diagrams and their variations. The performative capacity of a neural circuit is indeed qualitatively altered in a rapid and reversible way by various substances, called neuromodulators, in the extracellular fluid. This paper focuses on two properties of neuromodulatory action that are relatively neglected in current computational models of neuromodulation: the functional soundness of neuromodulated circuits and the robustness of neuromodulatory action. Both properties are examined here as sources of functional specifications for computational models of neuromodulatory action. In particular, it is pointed out that in a computational model based on CTRNNs (Continuous Time Recurrent Neural Networks) robustness can be modeled through a hysteresis process and functional soundness through a multiplicity of stable fixed points of the dynamic system.
File in questo prodotto:
File Dimensione Formato  
Prevete Tamburrini neuromodulazione capacita performative.docx

non disponibili

Tipologia: Documento in Pre-print
Licenza: Accesso privato/ristretto
Dimensione 1.23 MB
Formato Microsoft Word XML
1.23 MB Microsoft Word XML   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11588/748180
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact