N6-isopentenyladenosine (iPA) is an intermediate of the mevalonate pathway that exhibits various anti-cancer effects. However, studies on its anti-inflammatory activity are scarce and underlying molecular mechanisms are unknown. Therefore, we aimed to investigate the ability of iPA to exert anti-inflammatory effects in the human cystic fibrosis (CF) cell model of exacerbated inflammation.

The isoprenoid end product N6-isopentenyladenosine reduces inflammatory response through the inhibition of the NFκB and STAT3 pathways in cystic fibrosis cells / Santoro, Antonietta; Ciaglia, Elena; Nicolin, Vanessa; Pescatore, Alessandra; Prota, Lucia; Capunzo, Mario; Ursini, Matilde V; Nori, Stefania L; Bifulco, Maurizio. - In: INFLAMMATION RESEARCH. - ISSN 1023-3830. - 67:4(2018), pp. 315-326. [10.1007/s00011-017-1123-6]

The isoprenoid end product N6-isopentenyladenosine reduces inflammatory response through the inhibition of the NFκB and STAT3 pathways in cystic fibrosis cells

PESCATORE, ALESSANDRA;Bifulco, Maurizio
2018

Abstract

N6-isopentenyladenosine (iPA) is an intermediate of the mevalonate pathway that exhibits various anti-cancer effects. However, studies on its anti-inflammatory activity are scarce and underlying molecular mechanisms are unknown. Therefore, we aimed to investigate the ability of iPA to exert anti-inflammatory effects in the human cystic fibrosis (CF) cell model of exacerbated inflammation.
2018
The isoprenoid end product N6-isopentenyladenosine reduces inflammatory response through the inhibition of the NFκB and STAT3 pathways in cystic fibrosis cells / Santoro, Antonietta; Ciaglia, Elena; Nicolin, Vanessa; Pescatore, Alessandra; Prota, Lucia; Capunzo, Mario; Ursini, Matilde V; Nori, Stefania L; Bifulco, Maurizio. - In: INFLAMMATION RESEARCH. - ISSN 1023-3830. - 67:4(2018), pp. 315-326. [10.1007/s00011-017-1123-6]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/746986
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