Platinum(II) complexes with different cinnamic acid derivatives as ligands were investigated for their ability to inhibit the aggregation process of amyloid systems derived from Aβ, Yeast Prion Protein Sup35p and the C-terminal domain of nucleophosmin 1. Thioflavin T binding assays and circular dichroism data indicate that these compounds strongly inhibit the aggregation of investigated peptides exhibiting IC50 values in the micromolar range. MS analysis confirms the formation of adducts between peptides and Pt(II) complexes that are also able to reduce amyloid cytotoxicity in human SH-SY5Y neuroblastoma cells. Overall data suggests that bidentate ligands based on β-hydroxy dithiocinnamic esters can be used to develop platinum or platinoid compounds with anti-amyloid aggregation properties.

Platinum(II) O,S Complexes Inhibit the Aggregation of Amyloid Model Systems / Florio, Daniele; Malfitano, Anna Maria; Di Somma, Sarah; Mügge, Carolin; Weigand, Wolfgang; Ferraro, Giarita; Iacobucci, Ilaria; Monti, Maria; Morelli, Giancarlo; Merlino, Antonello; Marasco, Daniela. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 20:4(2019), p. 829. [10.3390/ijms20040829]

Platinum(II) O,S Complexes Inhibit the Aggregation of Amyloid Model Systems

Malfitano, Anna Maria
Investigation
;
Di Somma, Sarah
Investigation
;
Ferraro, Giarita
Investigation
;
Iacobucci, Ilaria
Investigation
;
Monti, Maria
Investigation
;
Morelli, Giancarlo
Investigation
;
Merlino, Antonello
Writing – Original Draft Preparation
;
Marasco, Daniela
Ultimo
Project Administration
2019

Abstract

Platinum(II) complexes with different cinnamic acid derivatives as ligands were investigated for their ability to inhibit the aggregation process of amyloid systems derived from Aβ, Yeast Prion Protein Sup35p and the C-terminal domain of nucleophosmin 1. Thioflavin T binding assays and circular dichroism data indicate that these compounds strongly inhibit the aggregation of investigated peptides exhibiting IC50 values in the micromolar range. MS analysis confirms the formation of adducts between peptides and Pt(II) complexes that are also able to reduce amyloid cytotoxicity in human SH-SY5Y neuroblastoma cells. Overall data suggests that bidentate ligands based on β-hydroxy dithiocinnamic esters can be used to develop platinum or platinoid compounds with anti-amyloid aggregation properties.
2019
Platinum(II) O,S Complexes Inhibit the Aggregation of Amyloid Model Systems / Florio, Daniele; Malfitano, Anna Maria; Di Somma, Sarah; Mügge, Carolin; Weigand, Wolfgang; Ferraro, Giarita; Iacobucci, Ilaria; Monti, Maria; Morelli, Giancarlo; Merlino, Antonello; Marasco, Daniela. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 20:4(2019), p. 829. [10.3390/ijms20040829]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/742469
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