Staphylococcus epidermidis, a harmless human skin colonizer, is a significant nosocomial pathogen in predisposed hosts because of its capability to form a biofilm on indwelling medical devices. In a recent paper, the purification and identification of the pentadecanal produced by the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125, able to impair S. epidermidis biofilm formation, were reported. Here the authors report on the chemical synthesis of pentadecanal derivatives, their anti-biofilm activity on S. epidermidis, and their action in combination with antibiotics. The results clearly indicate that the pentadecanal derivatives were able to prevent, to a different extent, biofilm formation and that pentadecanoic acid positively modulated the antimicrobial activity of the vancomycin. The cytotoxicity of these new anti-biofilm molecules was tested on two different immortalized eukaryotic cell lines in view of their potential applications.

Pentadecanal inspired molecules as new anti-biofilm agents against Staphylococcus epidermidis / Ricciardelli, Annarita; Casillo, Angela; Papa, Rosanna; Monti, Daria Maria; Imbimbo, Paola; Vrenna, Gianluca; Artini, Marco; Selan, Laura; Corsaro, Maria Michela; Tutino, Maria Luisa; Parrilli, Ermenegilda. - In: BIOFOULING. - ISSN 0892-7014. - 34:10(2018), pp. 1-11. [10.1080/08927014.2018.1544246]

Pentadecanal inspired molecules as new anti-biofilm agents against Staphylococcus epidermidis

Ricciardelli, Annarita;Casillo, Angela;Monti, Daria Maria;Imbimbo, Paola;Corsaro, Maria Michela;Tutino, Maria Luisa;Parrilli, Ermenegilda
2018

Abstract

Staphylococcus epidermidis, a harmless human skin colonizer, is a significant nosocomial pathogen in predisposed hosts because of its capability to form a biofilm on indwelling medical devices. In a recent paper, the purification and identification of the pentadecanal produced by the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125, able to impair S. epidermidis biofilm formation, were reported. Here the authors report on the chemical synthesis of pentadecanal derivatives, their anti-biofilm activity on S. epidermidis, and their action in combination with antibiotics. The results clearly indicate that the pentadecanal derivatives were able to prevent, to a different extent, biofilm formation and that pentadecanoic acid positively modulated the antimicrobial activity of the vancomycin. The cytotoxicity of these new anti-biofilm molecules was tested on two different immortalized eukaryotic cell lines in view of their potential applications.
2018
Pentadecanal inspired molecules as new anti-biofilm agents against Staphylococcus epidermidis / Ricciardelli, Annarita; Casillo, Angela; Papa, Rosanna; Monti, Daria Maria; Imbimbo, Paola; Vrenna, Gianluca; Artini, Marco; Selan, Laura; Corsaro, Maria Michela; Tutino, Maria Luisa; Parrilli, Ermenegilda. - In: BIOFOULING. - ISSN 0892-7014. - 34:10(2018), pp. 1-11. [10.1080/08927014.2018.1544246]
File in questo prodotto:
File Dimensione Formato  
Ricciardelli et al 2019.pdf

solo utenti autorizzati

Tipologia: Documento in Post-print
Licenza: Accesso privato/ristretto
Dimensione 1.47 MB
Formato Adobe PDF
1.47 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/732292
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 20
  • ???jsp.display-item.citation.isi??? 22
social impact