The title compound 4-{4-[(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-3-phenyl-3H-pyrrolo[2,3- c]quinoline 1, a compound that showed cytotoxic potential against two leukemia cell lines, has been synthesized via a multi-step pathway. This compound was characterized by single-crystal X-ray diffraction, IR, MS, elemental analysis, 1H and 13C NMR. The crystal ( C37H33H5O, Mr = 563.68) belongs to orthorhombic, space group Pbcn with cell parameters a = 30.198(2) Å, b = 12.5097(11) Å, c = 15.6648(13) Å, V = 5917.7(8) Å3, Z = 8, Dc = 1.265 g/cm3, CuKα radiation,λ = 1.54180 Å, μ = 0.611 mm−1, F(000) = 2384, the final R = 0.0491 and wR = 0.1585 for 5698 observed reflections with I > 2σ(I).

Synthesis, Crystal Structure and Anti-leukemic Activity of 4-4-[(4-(2-Oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]-3-phenyl-3H-pyrrolo[2,3-c]quinoline / Guillon, Jean; Moreau, Stéphane; Desplat, Vanessa; Vincenzi, Marian; Pinaud, Noël; Savrimoutou, Solène; Rubio, Sandra; Ronga, Luisa; Rossi, Filomena; Marchivie, Mathieu. - In: JOURNAL OF CHEMICAL CRYSTALLOGRAPHY. - ISSN 1074-1542. - 49:(2019), pp. 106-112. [10.1007/s10870-018-0734-2]

Synthesis, Crystal Structure and Anti-leukemic Activity of 4-4-[(4-(2-Oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]-3-phenyl-3H-pyrrolo[2,3-c]quinoline

Rossi, Filomena
Writing – Original Draft Preparation
;
2019

Abstract

The title compound 4-{4-[(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-3-phenyl-3H-pyrrolo[2,3- c]quinoline 1, a compound that showed cytotoxic potential against two leukemia cell lines, has been synthesized via a multi-step pathway. This compound was characterized by single-crystal X-ray diffraction, IR, MS, elemental analysis, 1H and 13C NMR. The crystal ( C37H33H5O, Mr = 563.68) belongs to orthorhombic, space group Pbcn with cell parameters a = 30.198(2) Å, b = 12.5097(11) Å, c = 15.6648(13) Å, V = 5917.7(8) Å3, Z = 8, Dc = 1.265 g/cm3, CuKα radiation,λ = 1.54180 Å, μ = 0.611 mm−1, F(000) = 2384, the final R = 0.0491 and wR = 0.1585 for 5698 observed reflections with I > 2σ(I).
2019
Synthesis, Crystal Structure and Anti-leukemic Activity of 4-4-[(4-(2-Oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]-3-phenyl-3H-pyrrolo[2,3-c]quinoline / Guillon, Jean; Moreau, Stéphane; Desplat, Vanessa; Vincenzi, Marian; Pinaud, Noël; Savrimoutou, Solène; Rubio, Sandra; Ronga, Luisa; Rossi, Filomena; Marchivie, Mathieu. - In: JOURNAL OF CHEMICAL CRYSTALLOGRAPHY. - ISSN 1074-1542. - 49:(2019), pp. 106-112. [10.1007/s10870-018-0734-2]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/728886
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