Insulin resistance, mTOR and hidradenitis suppurativa

Patients with hidradenitis suppurativa (HS) have a significantly higher prevalence of insulin resistance, as previously shown in our experience. Our study has analysed homoeostasis model assessment of insulin resistance (HOMA‐IR) in HS and healthy subjects with patients having higher values (P = 0.023). Moreover, we have assessed rate of glucose and insulin secretion after oral glucose tolerance test (OGTT). HS patients showed a significant difference, regarding insulin but not glucose rate, with respect to healthy subjects. Similarly to the results found by Vilanova1, HS subjects affected by insulin resistance showed a correlation with disease severity as well as among the latter one and BMI. Taking into account the high prevalence of obesity as well as metabolic syndrome in HS patients, especially in some countries, we strongly believe that it is necessary to evaluate glucose metabolism in all HS patients