Evidence from observational studies of telomere length (TL) has been conflicting regarding its direction of association with cancer risk. We investigated the causal relevance of TL for lung and head and neck cancers using Mendelian Randomization (MR) and mediation analyses.

Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers / Kachuri, Linda; Saarela, Olli; Bojesen, Stig Egil; Davey Smith, George; Liu, Geoffrey; Landi, Maria Teresa; Caporaso, Neil E; Christiani, David C; Johansson, Mattias; Panico, Salvatore; Overvad, Kim; Trichopoulou, Antonia; Vineis, Paolo; Scelo, Ghislaine; Zaridze, David; Wu, Xifeng; Albanes, Demetrius; Diergaarde, Brenda; Lagiou, Pagona; Macfarlane, Gary J; Aldrich, Melinda C; Tardón, Adonina; Rennert, Gad; Olshan, Andrew F; Weissler, Mark C; Chen, Chu; Goodman, Gary E; Doherty, Jennifer A; Ness, Andrew R; Bickeböller, Heike; Wichmann, H-Erich; Risch, Angela; Field, John K; Teare, M Dawn; Kiemeney, Lambertus A; van der Heijden, Erik H F M; Carroll, June C; Haugen, Aage; Zienolddiny, Shanbeh; Skaug, Vidar; Wünsch-Filho, Victor; Tajara, Eloiza H; Ayoub Moysés, Raquel; Daumas Nunes, Fabio; Lam, Stephen; Eluf-Neto, Jose; Lacko, Martin; Peters, Wilbert H M; Le Marchand, Loïc; Duell, Eric J; Andrew, Angeline S; Franceschi, Silvia; Schabath, Matthew B; Manjer, Jonas; Arnold, Susanne; Lazarus, Philip; Mukeriya, Anush; Swiatkowska, Beata; Janout, Vladimir; Holcatova, Ivana; Stojsic, Jelena; Mates, Dana; Lissowska, Jolanta; Boccia, Stefania; Lesseur, Corina; Zong, Xuchen; Mckay, James D; Brennan, Paul; Amos, Christopher I; Hung, Rayjean J. - In: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. - ISSN 0300-5771. - 48:3(2019), pp. 751-766. [10.1093/ije/dyy140]

Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers

Panico, Salvatore;
2019

Abstract

Evidence from observational studies of telomere length (TL) has been conflicting regarding its direction of association with cancer risk. We investigated the causal relevance of TL for lung and head and neck cancers using Mendelian Randomization (MR) and mediation analyses.
2019
Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers / Kachuri, Linda; Saarela, Olli; Bojesen, Stig Egil; Davey Smith, George; Liu, Geoffrey; Landi, Maria Teresa; Caporaso, Neil E; Christiani, David C; Johansson, Mattias; Panico, Salvatore; Overvad, Kim; Trichopoulou, Antonia; Vineis, Paolo; Scelo, Ghislaine; Zaridze, David; Wu, Xifeng; Albanes, Demetrius; Diergaarde, Brenda; Lagiou, Pagona; Macfarlane, Gary J; Aldrich, Melinda C; Tardón, Adonina; Rennert, Gad; Olshan, Andrew F; Weissler, Mark C; Chen, Chu; Goodman, Gary E; Doherty, Jennifer A; Ness, Andrew R; Bickeböller, Heike; Wichmann, H-Erich; Risch, Angela; Field, John K; Teare, M Dawn; Kiemeney, Lambertus A; van der Heijden, Erik H F M; Carroll, June C; Haugen, Aage; Zienolddiny, Shanbeh; Skaug, Vidar; Wünsch-Filho, Victor; Tajara, Eloiza H; Ayoub Moysés, Raquel; Daumas Nunes, Fabio; Lam, Stephen; Eluf-Neto, Jose; Lacko, Martin; Peters, Wilbert H M; Le Marchand, Loïc; Duell, Eric J; Andrew, Angeline S; Franceschi, Silvia; Schabath, Matthew B; Manjer, Jonas; Arnold, Susanne; Lazarus, Philip; Mukeriya, Anush; Swiatkowska, Beata; Janout, Vladimir; Holcatova, Ivana; Stojsic, Jelena; Mates, Dana; Lissowska, Jolanta; Boccia, Stefania; Lesseur, Corina; Zong, Xuchen; Mckay, James D; Brennan, Paul; Amos, Christopher I; Hung, Rayjean J. - In: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. - ISSN 0300-5771. - 48:3(2019), pp. 751-766. [10.1093/ije/dyy140]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/726129
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 28
  • ???jsp.display-item.citation.isi??? 25
social impact