Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies

Pennells, Lisa; Kaptoge, Stephen; Wood, Angela; Sweeting, Mike; Zhao, Xiaohui; White, Ian; Burgess, Stephen; Willeit, Peter; Bolton, Thomas; Moons, Karel G M; Van Der Schouw, Yvonne T; Selmer, Randi; Khaw, Kay-Tee; Gudnason, Vilmundur; Assmann, Gerd; Amouyel, Philippe; Salomaa, Veikko; Kivimaki, Mika; Nordestgaard, Børge G; Blaha, Michael J; Kuller, Lewis H; Brenner, Hermann; Gillum, Richard F; Meisinger, Christa; Ford, Ian; Knuiman, Matthew W; Rosengren, Annika; Lawlor, Debbie A; Völzke, Henry; Cooper, Cyrus; Marín Ibañez, Alejandro; Casiglia, Edoardo; Kauhanen, Jussi; Cooper, Jackie A; Rodriguez, Beatriz; Sundström, Johan; Barrett-Connor, Elizabeth; Dankner, Rachel; Nietert, Paul J; Davidson, Karina W; Wallace, Robert B; Blazer, Dan G; Björkelund, Cecilia; Donfrancesco, Chiara; Krumholz, Harlan M; Nissinen, Aulikki; Davis, Barry R; Coady, Sean; Whincup, Peter H; Jørgensen, Torben; Ducimetiere, Pierre; Trevisan, Maurizio; Engström, Gunnar; Crespo, Carlos J; Meade, Tom W; Visser, Marjolein; Kromhout, Daan; Kiechl, Stefan; Daimon, Makoto; Price, Jackie F; Gómez De La Cámara, Agustin; Wouter Jukema, J; Lamarche, Benoît; Onat, Altan; Simons, Leon A; Kavousi, Maryam; Ben-Shlomo, Yoav; Gallacher, John; Dekker, Jacqueline M; Arima, Hisatomi; Shara, Nawar; Tipping, Robert W; Roussel, Ronan; Brunner, Eric J; Koenig, Wolfgang; Sakurai, Masaru; Pavlovic, Jelena; Gansevoort, Ron T; Nagel, Dorothea; Goldbourt, Uri; Barr, Elizabeth L M; Palmieri, Luigi; Njølstad, Inger; Sato, Shinichi; Monique Verschuren, W M; Varghese, Cherian V; Graham, Ian; Onuma, Oyere; Greenland, Philip; Woodward, Mark; Ezzati, Majid; Psaty, Bruce M; Sattar,; Naveerobert, W Tipping; Lara, M Simpson; Sara, L Pressel; David, J Couper; Nambi, Vijay; Matsushita, Kunihiro; Aaron, R Folsom; Jonathan, E Shaw; Dianna, J Magliano; Paul, Z Zimmet; Matthew, W Knuiman; Peter, H Whincup; S Goya Wannamethee,; Willeit, Johann; Santer, Peter; Egger, Georg; Juan Pablo Casas,; Amuzu, Antoinette; Ben-Shlomo, Yoav; Gallacher, John; Tikhonoff, Valérie; Casiglia, Edoardo; Susan, E Sutherland; Paul, J Nietert; Cushman, Mary; Bruce, M Psaty; Anne Johanne Søgaard,; Lise Lund Håheim,; Ariansen, Inger; Tybjærg-Hansen, Anne; Gorm, B Jensen; Schnohr, Peter; Giampaoli, Simona; Vanuzzo, Diego; Panico, Salvatore; Palmieri, Luigi; Balkau, Beverley; Bonnet, Fabrice; Marre, Michel; Agustin Gómez De La Cámara,; Miguel Angel Rubio Herrera,; Friedlander, Yechiel; Mccallum, John; Mclachlan, Stela; Guralnik, Jack; Caroline, L Phillips; Khaw, Kay-Tee; Wareham, Nick; Schöttker, Ben; Saum, Kai-Uwe; Holleczek, Bernd; Nissinen, Aulikki; Tolonen, Hanna; Giampaoli, Simona; Donfrancesco, Chiara; Vartiainen, Erkki; Jousilahti, Pekka; Harald, Kennet; Ralph, B D’Agostino; Joseph, M Massaro; Pencina, Michael; Vasan, Ramachandran; Kayama, Takamasa; Kato, Takeo; Oizumi, Toshihide; Jespersen, Jørgen; Møller, Lars; Else Marie Bladbjerg,; Chetrit, A; Rosengren, Annika; Wilhelmsen, Lars; Björkelund, Cecilia; Lissner, Lauren; Nagel, Dorothea; Dennison, Elaine; Kiyohara, Yutaka; Ninomiya, Toshiharu; Doi, Yasufumi; Rodriguez, Beatriz; Nijpels, Giel; Coen D, A Stehouwer; Sato, Shinichi; Kazumasa, Yamagishi; Iso, Hiroyasu; Goldbourt, Uri; Salomaa, Veikko; Vartiainen, Erkki; Kurl, Sudhir; Tuomainen, Tomi-Pekka; Jukka, T Salonen; Visser, Marjolein; Dorly J, H Deeg; Tom, W Meade; Peter, M Nilsson; Hedblad, Bo; Melander, Olle; Ian, H De Boer; Andrew Paul Defilippis,; M Monique Verschuren, W; Sattar, Naveed; Watt, Graham; Meisinger, Christa; Koenig, Wolfgang; Rosengren, Annika; Lewis, H Kuller; Tverdal, Aage; Richard, F Gillum; Jackie, A Cooper; Kirkland, Susan; Shimbo, Daichi; Shaffer, Jonathan; Sato, Shinichi; Kazumasa, Yamagishi; Iso, Hiroyasu; Ducimetiere, Pierre; Stephan J, L Bakker; Pim Van Der Harst,; Hans, L Hillege; Carlos, J Crespo; Amouyel, Philippe; Dallongeville, Jean; Assmann, Gerd; Schulte, Helmut; Trompet, Stella; Roelof A, J Smit; David, J Stott; Yvonne, T Van Der Schouw; Després, Jean-Pierre; Cantin, Bernard; Gilles, R Dagenais; Laughlin, Gail; Wingard, Deborah; Trevisan, Maurizio; Aspelund, Thor; Eiriksdottir, Gudny; Elias Freyr Gudmundsson,; Ikram, Arfan; Frank J, A Van Rooij; Oscar, H Franco; Oscar, L Rueda-Ochoa; Muka, Taulant; Glisic, Marija; Tunstall-Pedoe, Hugh; Völzke, Henry; Barbara, V Howard; Zhang, Ying; Jolly, Stacey; Gallacher, John; Davey-Smith, George; Can, Günay; Yüksel, Hüsniye; Nakagawa, Hideaki; Morikawa, Yuko; Miura, Katsuyuki; Njølstad, Inger; Ingelsson, Martin; Giedraitis, Vilmantas; Paul, M Ridker; J Michael Gaziano,; Kivimaki, Mika; Shipley, Martin; Eric, J Brunner; Arndt, Volker; Brenner, Hermann; Cook, Nancy; Paul, M Ridker; Ford, Ian; Sattar, Naveed; Alejandro Marín Ibañez,; Johanna, M Geleijnsed; Jackson, Rod; Ridker, Paul M; Cook, Nancy R; D'Agostino, Ralph B; Thompson, Simon G; Danesh, John; Di Angelantonio, Emanuele

doi:10.1093/eurheartj/ehy653

There is debate about the optimum algorithm for cardiovascular disease (CVD) risk estimation. We conducted head-to-head comparisons of four algorithms recommended by primary prevention guidelines, before and after 'recalibration', a method that adapts risk algorithms to take account of differences in the risk characteristics of the populations being studied.

Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies / Lisa, P., Stephen, K., Angela, W., Mike, S., Xiaohui, Z., Ian, W., Stephen, B., Peter, W., Thomas, B., Karel G M, M., Yvonne T, v.d.S., Randi, S., Kay-Tee, K., Vilmundur, G., Gerd, A., Philippe, A., Veikko, S., Mika, K., Børge G, N., Michael J, B., et al.. - In: EUROPEAN HEART JOURNAL. - ISSN 1522-9645. - 40:7(2019), pp. 621-631. [10.1093/eurheartj/ehy653]