Adiponectin is a relevant cytokine linking energy metabolism and immune system. After being assembled, adiponectin circulates as oligomers of different molecular weight, LMW, MMW and HMW. These latter have the most potent biological effects. Multiple Sclerosis (MS) is an autoimmune disease of human central nervous system. The aim of this study was to characterize the expression levels of both total Adiponectin and its oligomerization state in the serum from 99 MS patients at the baseline (i.e. not influenced by therapies); we also investigated the potential relationships between Adiponectin and disease progression and severity.
Adiponectin profile at baseline is correlated to progression and severity of Multiple Sclerosis / Signoriello, E; Lus, G; Polito, R; Casertano, S; Scudiero, O; Coletta, M; Monaco, Ml; Rossi, F; Nigro, E; Daniele, A. - In: EUROPEAN JOURNAL OF NEUROLOGY. - ISSN 1468-1331. - 26:2(2019), pp. 348-355. [10.1111/ene.13822]
Adiponectin profile at baseline is correlated to progression and severity of Multiple Sclerosis
Lus G;Scudiero O;Daniele A
2019
Abstract
Adiponectin is a relevant cytokine linking energy metabolism and immune system. After being assembled, adiponectin circulates as oligomers of different molecular weight, LMW, MMW and HMW. These latter have the most potent biological effects. Multiple Sclerosis (MS) is an autoimmune disease of human central nervous system. The aim of this study was to characterize the expression levels of both total Adiponectin and its oligomerization state in the serum from 99 MS patients at the baseline (i.e. not influenced by therapies); we also investigated the potential relationships between Adiponectin and disease progression and severity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
