Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent and debilitating skin disease of the hair follicle, which usually occurs after puberty with painful, deep-seated, inflammatory lesions in the apocrine gland-bearing areas of the body. In psoriasis, a strong action on mTORC1 of etanercept, anti-TNF-a agent, has previously assessed. Here too, the difference in staining of P-S6K1 was observed in responder and non-responder patients.8 In conclusion, mTORC1 pathway is modulated by anti-TNF-a treatment, highlighting a possible new mechanism by which TNF-a inhibition improves HS.

Anti-TNF-α therapy modulates mTORC1 signalling in hidradenitis suppurativa

Balato A;Caiazzo G;Annunziata MC;Marasca C;Scala E;Cacciapuoti S;Fabbrocini G.
2019

Abstract

Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent and debilitating skin disease of the hair follicle, which usually occurs after puberty with painful, deep-seated, inflammatory lesions in the apocrine gland-bearing areas of the body. In psoriasis, a strong action on mTORC1 of etanercept, anti-TNF-a agent, has previously assessed. Here too, the difference in staining of P-S6K1 was observed in responder and non-responder patients.8 In conclusion, mTORC1 pathway is modulated by anti-TNF-a treatment, highlighting a possible new mechanism by which TNF-a inhibition improves HS.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/722329
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