Phytochemical investigation of the apolar extract obtained from aerial parts of the Iranian endemic plant Echinophora platyloba DC (Apiaceae) resulted in the characterization of the polyacetylene fraction of this plant. This resulted to be composed of the known echinophorins A and B, embedding the very rare α-pyrone terminal, and of the new echinophorin D (3), including also three conjugated triple bonds. The chemical structures of these compounds were secured by detailed inspection of MS and 1D/2D NMR spectra. The isolated polyacteylenes were evaluated for their modulation of six thermo-TRP channels and they revealed a selective activity on TRPA1, an ion channel involved in the mediation of neuropathic and inflammatory pain. This is the first report on the activity of plant polyacetylenes on transient receptor potential (TRP) channels.
TRPA1 Modulating C14 Polyacetylenes from the Iranian Endemic Plant Echinophora platyloba / Chianese, Giuseppina; Sirignano, Carmina; Shokoohinia, Yalda; Mohammadi, Zeynab; Bazvandi, Leili; Jafari, Fataneh; Jalilian, Fereshteh; Schiano Moriello, Aniello; De Petrocellis, Luciano; Taglialatela-Scafati, Orazio; Rigano, Daniela. - In: MOLECULES. - ISSN 1420-3049. - 23:7(2018), p. 1750. [10.3390/molecules23071750]
TRPA1 Modulating C14 Polyacetylenes from the Iranian Endemic Plant Echinophora platyloba
Chianese, GiuseppinaMembro del Collaboration Group
;Sirignano, CarminaMembro del Collaboration Group
;Taglialatela-Scafati, Orazio
Supervision
;Rigano, DanielaUltimo
Membro del Collaboration Group
2018
Abstract
Phytochemical investigation of the apolar extract obtained from aerial parts of the Iranian endemic plant Echinophora platyloba DC (Apiaceae) resulted in the characterization of the polyacetylene fraction of this plant. This resulted to be composed of the known echinophorins A and B, embedding the very rare α-pyrone terminal, and of the new echinophorin D (3), including also three conjugated triple bonds. The chemical structures of these compounds were secured by detailed inspection of MS and 1D/2D NMR spectra. The isolated polyacteylenes were evaluated for their modulation of six thermo-TRP channels and they revealed a selective activity on TRPA1, an ion channel involved in the mediation of neuropathic and inflammatory pain. This is the first report on the activity of plant polyacetylenes on transient receptor potential (TRP) channels.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
