Clinical, pathological and genetic overlap between sporadic frontotemporal dementia (FTD), Alzheimer's disease (AD) and Parkinson's disease (PD) has been suggested; however, the relationship between these disorders is still not well understood. Here we evaluated genetic overlap between FTD, AD and PD to assess shared pathobiology and identify novel genetic variants associated with increased risk for FTD.
Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases / Ferrari, R; Wang, Y; Vandrovcova, J; Guelfi, S; Witeolar, A; Karch, Cm; Schork, Aj; Fan, Cc; Brewer, Jb; International FTD-Genomics Consortium, (IFGC); International Parkinson's Disease Genomics Consortium, (IPDGC); International Genomics of Alzheimer's Project, (IGAP); Momeni, P; Schellenberg, Gd; Dillon, Wp; Sugrue, Lp; Hess, Cp; Yokoyama, Js; Bonham, Lw; Rabinovici, Gd; Miller, Bl; Andreassen, Oa; Dale, Am; Hardy, J; Desikan, Rs; Collaborators: Ferrari, R; Hernandez, Dg; Nalls, Ma; Rohrer, Jd; Ramasamy, A; Kwok, Jbj; Dobson-Stone, C; Schofield, Pr; Halliday, Gm; Hodges, Jr; Piguet, O; Bartley, L; Thompson, E; Haan, E; Hernández, I; Ruiz, A; Boada, M; Borroni, B; Padovani, A; Cruchaga, C; Cairns, Nj; Benussi, L; Binetti, G; Ghidoni, R; Forloni, G; Albani, D; Galimberti, D; Fenoglio, C; Serpente, M; Scarpini, E; Clarimón, J; Lleó, A; Blesa, R; Landqvist Waldö, M; Nilsson, C; Mackenzie, Ira; Hsiung, Gyr; Mann, Dma; Grafman, J; Morris, Cm; Attems, J; Griffiths, Td; Mckeith, Ig; Thomas, Aj; Pietrini, P; Huey, Ed; Wassermann, Em; Baborie, A; Jaros, E; Tierney, Mc; Pastor, P; Razquin, C; Ortega-Cubero, S; Alonso, E; Perneczky, R; Diehl-Schmid, J; Alexopoulos, P; Kurz, A; Rainero, I; Rubino, E; Pinessi, L; Rogaeva, E; St George-Hyslop, P; Rossi, G; Tagliavini, F; Giaccone, G; Rowe, Jb; Schlachetzki, Jcm; Uphill, J; Collinge, J; Mead, S; Danek, A; Van Deerlin, Vm; Grossman, M; Trojanowski, Jq; van der Zee, J; Cruts, M; Van Broeckhoven, C; Cappa, Sf; Leber, I; Hannequin, D; Golfier, V; Vercelletto, M; Brice, A; Nacmias, B; Sorbi, S; Bagnoli, S; Piaceri, I; Nielsen, Je; Hjermind, Le; Riemenschneider, M; Mayhaus, M; Ibach, B; Gasparoni, G; Pichler, S; Gu, W; Rossor, Mn; Fox, Nc; Warren, Jd; Spillantini, Mg; Morris, Hr; Rizzu, P; Heutink, P; Snowden, Js; Rollinson, S; Richardson, A; Gerhard, A; Bruni, Ac; Maletta, R; Frangipane, F; Cupidi, C; Bernardi, L; Anfossi, M; Gallo, M; Conidi, Me; Smirne, N; Rademakers, R; Baker, M; Dickson, Dw; Graff-Radford, Nr; Petersen, Rc; Knopman, D; Josephs, Ka; Boeve, Bf; Parisi, Je; Seeley, Ww; Miller, Bl; Karydas, Am; Rosen, H; van Swieten, Jc; Dopper, Eg; Seelaar, H; Pijnenburg, Yal; Scheltens, P; Logroscino, G; Capozzo, R; Novelli, V; Puca, Aa; Franceschi, M; Postiglione, A; Milan, G; Sorrentino, P; Kristiansen, M; Chiang, Hh; Graff, C; Pasquier, F; Rollin, A; Deramecourt, V; Lebouvier, T; Kapogiannis, D; Ferrucci, L; Pickering-Brown, S; Singleton, Ab; Hardy, J; Momeni, P.. - In: JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY. - ISSN 0022-3050. - 88:2(2017), pp. 152-164. [10.1136/jnnp-2016-314411]
Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases
Postiglione AMembro del Collaboration Group
;
2017
Abstract
Clinical, pathological and genetic overlap between sporadic frontotemporal dementia (FTD), Alzheimer's disease (AD) and Parkinson's disease (PD) has been suggested; however, the relationship between these disorders is still not well understood. Here we evaluated genetic overlap between FTD, AD and PD to assess shared pathobiology and identify novel genetic variants associated with increased risk for FTD.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
