Diarrhea is a severe complication in HIV-1-infected patients with Trans-activator of transcription (HIV-1 Tat) protein being recognized as a major underlying cause. Beside its direct enterotoxic effects, Tat protein has been recently shown to affect enteric glial cell (EGC) activity. EGCs regulate intestinal inflammatory responses by secreting pro-inflammatory molecules; nonetheless, they might also release immune-regulatory factors, as palmytoilethanolamide (PEA), which exerts anti-inflammatory effects by activating PPARα receptors. We aimed at clarifying whether EGCs are involved in HIV-1 Tat-induced diarrhea and if PEA exerts antidiarrheal activity.

HIV-1 Tat-induced diarrhea is improved by the PPARalpha agonist, palmitoylethanolamide, by suppressing the activation of enteric glia / Sarnelli, Giovanni; Seguella, Luisa; Pesce, Marcella; Lu, Jie; Gigli, Stefano; Bruzzese, Eugenia; Lattanzi, Roberta; D'Alessandro, Alessandra; Cuomo, Rosario; Steardo, Luca; Esposito, Giuseppe. - In: JOURNAL OF NEUROINFLAMMATION. - ISSN 1742-2094. - 15:1(2018), p. 94. [10.1186/s12974-018-1126-4]

HIV-1 Tat-induced diarrhea is improved by the PPARalpha agonist, palmitoylethanolamide, by suppressing the activation of enteric glia

Sarnelli, Giovanni
;
Pesce, Marcella;Bruzzese, Eugenia;D'Alessandro, Alessandra;Cuomo, Rosario;Steardo, Luca;Esposito, Giuseppe
2018

Abstract

Diarrhea is a severe complication in HIV-1-infected patients with Trans-activator of transcription (HIV-1 Tat) protein being recognized as a major underlying cause. Beside its direct enterotoxic effects, Tat protein has been recently shown to affect enteric glial cell (EGC) activity. EGCs regulate intestinal inflammatory responses by secreting pro-inflammatory molecules; nonetheless, they might also release immune-regulatory factors, as palmytoilethanolamide (PEA), which exerts anti-inflammatory effects by activating PPARα receptors. We aimed at clarifying whether EGCs are involved in HIV-1 Tat-induced diarrhea and if PEA exerts antidiarrheal activity.
2018
HIV-1 Tat-induced diarrhea is improved by the PPARalpha agonist, palmitoylethanolamide, by suppressing the activation of enteric glia / Sarnelli, Giovanni; Seguella, Luisa; Pesce, Marcella; Lu, Jie; Gigli, Stefano; Bruzzese, Eugenia; Lattanzi, Roberta; D'Alessandro, Alessandra; Cuomo, Rosario; Steardo, Luca; Esposito, Giuseppe. - In: JOURNAL OF NEUROINFLAMMATION. - ISSN 1742-2094. - 15:1(2018), p. 94. [10.1186/s12974-018-1126-4]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/712746
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